de Oliveira Lucian Batista, de Figueiredo Martins Siqueira Mariana Andrade, de Macedo Gadêlha Rafael Buarque, Garcia Jessica, Bandeira Francisco
Division of Endocrinology and Diabetes, Agamenon Magalhães Hospital, University of Pernambuco (UPE), Faculty of Medical Sciences, Recife, PE, Brazil.
Division of Cardiology, Agamenon Magalhães Hospital, University of Pernambuco (UPE), Faculty of Medical Sciences, Recife, PE, Brazil.
Int J Heart Fail. 2023 Nov 14;6(2):84-90. doi: 10.36628/ijhf.2023.0025. eCollection 2024 Apr.
Vitamin D, as a steroid hormone, has multiple effects on human body and its deficiency has been associated with an increased risk of heart failure (HF) and unfavorable outcomes. The present study investigated the prevalence of vitamin D deficiency (VDD) and its relationship with cardiometabolic parameters in patients hospitalized for HF living in the city of Recife (latitude 8° South).
Analytical cross-sectional study, with men and women aged 40-64 years. The HF group was recruited during hospitalization due to decompensation. A matched control group was recruited from the general endocrine clinics. Vitamin D status was assessed by measuring serum 25-hydroxyvitamin D (25OHD), considering deficiency when 25OHD <20 ng/mL (<50 nmol/L).
A total of 243 patients were evaluated (HF group: 161, control group: 82). Lower serum 25OHD levels were observed in the HF group (25.2±9.4 vs. 30.0±7.7ng/mL; p<0.001), as well as a higher prevalence of VDD (27.3% vs. 9.8%; prevalence ratio, 2.80; 95% confidence interval, 1.38-5.67; p=0.002). In patients with HF, VDD was associated with diabetes mellitus (65.9% vs. 41.0%; p=0.005) and female sex (65.9% vs. 44.4%; p=0.015). In the subgroup with VDD, higher values of hemoglobin A1c (7.9% [6.0-8.9] vs. 6.2% [5.7-7.9]; p=0.006) and dyslipidemia were also observed.
We found higher rates of VDD in patients hospitalized for HF and this was associated with deleterious laboratory metabolic parameters.
维生素D作为一种类固醇激素，对人体有多种作用，其缺乏与心力衰竭（HF）风险增加及不良预后相关。本研究调查了累西腓市（南纬8°）因HF住院患者维生素D缺乏（VDD）的患病率及其与心脏代谢参数的关系。
分析性横断面研究，纳入年龄40 - 64岁的男性和女性。HF组在失代偿住院期间招募。从普通内分泌门诊招募匹配的对照组。通过测量血清25 - 羟基维生素D（25OHD）评估维生素D状态，当25OHD <20 ng/mL（<50 nmol/L）时视为缺乏。
共评估243例患者（HF组：161例，对照组：82例）。HF组血清25OHD水平较低（25.2±9.4 vs. 30.0±7.7 ng/mL；p<0.001），VDD患病率也较高（27.3% vs. 9.8%；患病率比，2.80；95%置信区间，1.38 - 5.67；p = 0.002）。在HF患者中，VDD与糖尿病（65.9% vs. 4l.0%；p = 0.005）和女性（65.9% vs. 44.4%；p = 0.015）相关。在VDD亚组中，还观察到糖化血红蛋白（HbA1c）值较高（7.9% [6.0 - 8.9] vs. 6.2% [5.7 - 7.9]；p = 0.006）和血脂异常。
我们发现因HF住院患者的VDD发生率较高，且这与有害的实验室代谢参数相关。
