Department of Occupational and Environmental Health, School of Public Health, Tianjin Medical University, Tianjin, China.
Key Laboratory of Prevention and Control of Major Diseases in the Population, Ministry of Education, Tianjin Medical University, Tianjin, China.
Front Public Health. 2024 Apr 17;12:1371920. doi: 10.3389/fpubh.2024.1371920. eCollection 2024.
An increasing number of studies suggest that environmental pollution may increase the risk of vitamin D deficiency (VDD). However, less is known about arsenic (As) exposure and VDD, particularly in Chinese pregnant women.
This study examines the correlations of different urinary As species with serum 25 (OH) D and VDD prevalence.
We measured urinary arsenite (As), arsenate (As), monomethylarsonic acid (MMA), and dimethylarsinic acid (DMA) levels and serum 25(OH)D, 25(OH)D, 25(OH) D levels in 391 pregnant women in Tianjin, China. The diagnosis of VDD was based on 25(OH) D serum levels. Linear relationship, Logistic regression, and Bayesian kernel machine regression (BKMR) were used to examine the associations between urinary As species and VDD.
Of the 391 pregnant women, 60 received a diagnosis of VDD. Baseline information showed significant differences in As, DMA, and tAs distribution between pregnant women with and without VDD. Logistic regression showed that As was significantly and positively correlated with VDD (OR: 4.65, 95% CI: 1.79, 13.32). Meanwhile, there was a marginally significant positive correlation between tAs and VDD (OR: 4.27, 95% CI: 1.01, 19.59). BKMR revealed positive correlations between As, MMA and VDD. However, negative correlations were found between As, DMA and VDD.
According to our study, there were positive correlations between iAs, especially As, MMA and VDD, but negative correlations between other As species and VDD. Further studies are needed to determine the mechanisms that exist between different As species and VDD.
越来越多的研究表明，环境污染可能会增加维生素 D 缺乏症（VDD）的风险。然而，对于砷（As）暴露与 VDD 的关系，人们知之甚少，特别是在中国孕妇中。
本研究旨在探讨不同尿砷形态与血清 25-羟维生素 D [25(OH)D]和 VDD 患病率之间的相关性。
我们检测了 391 名天津孕妇的尿砷酸盐（As）、砷酸盐（As）、一甲基砷酸（MMA）和二甲基砷酸（DMA）水平及血清 25（OH）D、25（OH）D 和 25（OH）D 水平。根据血清 25（OH）D 水平诊断 VDD。线性关系、Logistic 回归和贝叶斯核机器回归（BKMR）用于检验尿砷形态与 VDD 之间的关联。
391 名孕妇中，60 名被诊断为 VDD。VDD 孕妇与非 VDD 孕妇在砷、DMA 和总砷（tAs）分布方面存在显著差异。Logistic 回归表明，As 与 VDD 呈显著正相关（OR：4.65，95%CI：1.79，13.32）。同时，tAs 与 VDD 呈正相关（OR：4.27，95%CI：1.01，19.59），但相关性具有边际统计学意义。BKMR 分析结果表明，As、MMA 与 VDD 呈正相关，而 As、DMA 与 VDD 呈负相关。
本研究表明，iAs 尤其是 As 与 MMA 与 VDD 呈正相关，而其他 As 物种与 VDD 呈负相关。需要进一步研究以确定不同 As 物种与 VDD 之间的关系机制。
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