Eliasberg Claire D, Trinh Paula M P, Rodeo Scott A
HSS Sports Medicine Institute, Hospital for Special Surgery.
Orthopaedic Soft Tissue Research Program, Hospital for Special Surgery Research Institute.
Sports Med Arthrosc Rev. 2024 Mar 1;32(1):33-37. doi: 10.1097/JSA.0000000000000395. Epub 2024 May 2.
Rotator cuff disease is one of the most common human tendinopathies and can lead to significant shoulder dysfunction. Despite efforts to improve symptoms in patients with rotator cuff tears and healing rates after rotator cuff repair, high rates of failed healing and persistent shoulder morbidity exist. Increasing interest has been placed on the utilization of orthobiologics-scaffolds, cell-based augmentation, platelet right plasma (platelet-rich plasma), and small molecule-based strategies-in the management of rotator cuff disease and the augmentation of rotator cuff repairs. This is a complex topic that involves novel treatment strategies, including patches/scaffolds, small molecule-based, cellular-based, and tissue-derived augmentation techniques. Ultimately, translational research, with a particular focus on preclinical models, has allowed us to gain some insights into the utility of orthobiologics in the treatment of rotator cuff disease and will continue to be critical to our further understanding of the underlying cellular mechanisms moving forward.
肩袖疾病是人类最常见的肌腱病之一，可导致严重的肩部功能障碍。尽管人们努力改善肩袖撕裂患者的症状以及肩袖修复后的愈合率，但仍存在较高的愈合失败率和持续的肩部发病率。在肩袖疾病的管理和肩袖修复的强化方面，人们越来越关注使用骨科生物材料支架、基于细胞的增强技术、富血小板血浆和基于小分子的策略。这是一个复杂的话题，涉及新颖的治疗策略，包括贴片/支架、基于小分子的、基于细胞的和组织衍生的增强技术。最终，以临床前模型为特别重点的转化研究，使我们对骨科生物材料在肩袖疾病治疗中的效用有了一些认识，并将继续对我们进一步理解潜在的细胞机制至关重要。
