Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Department of Chemistry, Hamline University, St. Paul, Minnesota, 55104, USA.
Angew Chem Int Ed Engl. 2024 Aug 5;63(32):e202406676. doi: 10.1002/anie.202406676. Epub 2024 Jul 3.
We describe a full account of our synthetic strategy leading to the first total synthesis of the manzamine alkaloid lissodendoric acid A . These efforts demonstrate that strained cyclic allenes are valuable synthetic building blocks and can be employed efficiently in total synthesis.
我们描述了导致曼扎明生物碱利松多里酸 A 的首次全合成的综合策略的完整说明。这些努力表明，应变环状丙二烯是有价值的合成砌块，并可在全合成中有效地应用。
