Laboratory of Toxicology and Forensic Sciences, Medical School, University of Crete, Voutes, 71003, Heraklion, Greece.
Lifeplus S.A., Science &Technological Park of Crete, C Building, Vassilika Vouton, 70013, Heraklion, Crete, Greece.
J Assist Reprod Genet. 2024 Jun;41(6):1463-1473. doi: 10.1007/s10815-024-03117-6. Epub 2024 May 2.
The current article is a literature review aiming to provide an overview of the existing knowledge on the association between telomere length and telomerase activity and in vitro fertilization. Recently, telomeres have been used as an effective biomarker to determine biological age, which may differ from chronological age due to genetic, lifestyle, and environmental factors. Cellular senescence, along with other exogenous and mainly environmental factors, can enhance telomere wear, further shortening their ends and may also affect reproductive aging. IVF is a common fertility treatment caused by female reasons (age, ovulation disorders, damaged or blocked fallopian tubes, endometriosis), male reasons (low sperm quantity or quality), or unexplained infertility. A growing number of studies have proposed a relationship between telomere length and telomerase activity and IVF success and have suggested their use as candidate biomarkers for IVF outcome. Nevertheless, additional studies are necessary to be conducted, in order to clarify the possible implication of telomeres in IVF and to evaluate their possible role as valuable predictors of IVF result.
这篇文章是一篇文献综述，旨在提供关于端粒长度和端粒酶活性与体外受精之间关系的现有知识概述。最近，端粒被用作确定生物年龄的有效生物标志物，由于遗传、生活方式和环境因素的影响，生物年龄可能与实际年龄不同。细胞衰老以及其他外源性的主要环境因素会加速端粒磨损，进一步缩短端粒的末端，这也可能影响生殖衰老。体外受精（IVF）是一种常见的生育治疗方法，其原因包括女性因素（年龄、排卵障碍、输卵管受损或阻塞、子宫内膜异位症）、男性因素（精子数量或质量低）或不明原因的不孕。越来越多的研究提出了端粒长度和端粒酶活性与 IVF 成功之间的关系，并提出将其用作 IVF 结果的候选生物标志物。然而，还需要进行更多的研究，以阐明端粒在 IVF 中的可能作用，并评估它们作为 IVF 结果有价值的预测因子的可能作用。
