Institute of Medical Sciences, Department of Biology and Genetics, Faculty of Medicine, University of Opole, Oleska 48, 45-052 Opole, Poland.
Independent Laboratory of Cancer Diagnostics and Immunology, Medical University of Lublin, Chodźki 1, 20-093 Lublin, Poland.
Int J Mol Sci. 2024 Aug 8;25(16):8652. doi: 10.3390/ijms25168652.
The number of infertile couples undergoing in vitro fertilisation (IVF) has increased significantly. The efficacy of this procedure is contingent upon a multitude of factors, including gamete quality. One factor influencing gamete quality is oxidative stress, which leads to telomere damage and accelerates cellular ageing. Identifying new biomarkers that can predict the success of assisted reproduction techniques is a current relevant area of research. In this review, we discuss the potential role of SIRT1, a protein known to protect against oxidative stress and telomeres, which are responsible for genome stability, as biomarkers of gamete quality and assisted reproduction technique outcomes.
越来越多的不孕夫妇选择接受体外受精（IVF）。该程序的功效取决于多种因素，包括配子质量。影响配子质量的一个因素是氧化应激，它会导致端粒损伤并加速细胞衰老。寻找新的生物标志物来预测辅助生殖技术的成功是当前一个相关的研究领域。在这篇综述中，我们讨论了 SIRT1 的潜在作用，SIRT1 是一种已知能够对抗氧化应激和端粒的蛋白质，端粒负责基因组的稳定性，它可以作为配子质量和辅助生殖技术结果的生物标志物。
