烧伤瘢痕中发生的恶性黑色素瘤。

Malignant melanoma arising in a burn scar.

作者信息

Ma Emily, Ge Shealinna, Rush Walter L, Allbritton Jill

机构信息

University of Maryland School of Medicine, Baltimore Maryland, USA.

Department of Dermatology, University of Maryland Medical Center, Baltimore, MD, USA.

出版信息

Arch Dermatol Res. 2024 May 2;316(5):146. doi: 10.1007/s00403-024-02861-0.

DOI:10.1007/s00403-024-02861-0

PMID:38696005

Abstract

Secondary malignancies are rare but devastating complications of longstanding burn scars. Squamous cell carcinoma is the most common, followed by basal cell carcinoma and melanomas. There are fewer than 50 total reported cases of malignant melanomas arising in burn scars. We report a case of malignant melanoma arising within a longstanding burn scar confirmed by histology, FISH, and PRAME staining to further characterize melanomas arising in burn scars and to illustrate the diagnostic challenges they present.

摘要

继发性恶性肿瘤是长期烧伤瘢痕罕见但具有毁灭性的并发症。鳞状细胞癌最为常见，其次是基底细胞癌和黑色素瘤。烧伤瘢痕中发生恶性黑色素瘤的报道病例总数不到50例。我们报告了1例发生于长期烧伤瘢痕内的恶性黑色素瘤病例，通过组织学、荧光原位杂交（FISH）和黑色素瘤特异性抗原（PRAME）染色确诊，以进一步明确烧伤瘢痕中发生的黑色素瘤的特征，并说明其所带来的诊断挑战。