Akiyama M, Inamoto N, Nakamura K
Division of Dermatology, Kitasato Institute Hospital, Minato-ku, Tokyo, Japan.
Dermatology. 1997;194(2):157-61. doi: 10.1159/000246086.
Malignant melanoma occurring in burn scars is rare and cases of malignant melanoma and squamous cell carcinoma arising in a burn scar are extremely rare. We report a case of malignant melanoma and squamous cell carcinoma arising in one tumour on a stable thermal burn scar on the right leg of a 55-year-old man after a long latent period of about 50 years. The case was unique in that the malignant melanoma and squamous cell carcinoma occurred synchronously next to each other and produced one tumour. Immunohistochemical stainings with keratin, S-100 protein and HMB 45 clearly distinguished the two kinds of atypical tumour cells. Following the total resection of the original tumour, metastasis of malignant melanoma in the inguinal lymph node was found. This case underlines the possibility that another tumour may co-exist even if pathological observation reveals one kind of tumour.
发生于烧伤瘢痕的恶性黑色素瘤很罕见，而在烧伤瘢痕中同时出现恶性黑色素瘤和鳞状细胞癌的病例极为罕见。我们报告一例55岁男性右腿稳定热烧伤瘢痕上一个肿瘤中同时出现恶性黑色素瘤和鳞状细胞癌的病例，该病例经过了约50年的漫长潜伏期。此病例的独特之处在于恶性黑色素瘤和鳞状细胞癌彼此相邻同时出现并形成一个肿瘤。用角蛋白、S-100蛋白和HMB 45进行免疫组化染色可清晰区分这两种非典型肿瘤细胞。在对原发肿瘤进行全切除后，发现腹股沟淋巴结有恶性黑色素瘤转移。该病例强调了即使病理观察显示为一种肿瘤，也可能并存另一种肿瘤的可能性。
