Yusufoğlu Elif, Keser Sinem
Elazığ Fethi Sekin City Hospital, Eye Clinic, Elazig, Turkey.
Int Ophthalmol. 2024 May 2;44(1):211. doi: 10.1007/s10792-024-03128-3.
To evaluate the effects of sodium hyaluronate drops on dry eye parameters and corneal epithelial thickness following cataract surgery.
The study included 84 patients who underwent uncomplicated phacoemulsification. In Group A, 0.15% sodium hyaluronate drops were added to the postoperative antibiotic/anti-inflammatory treatment. In Group B, only antibiotic/anti-inflammatory treatment was applied. Preoperatively and at 1 week and 1 month postoperatively, all the patients were evaluated in respect of tear break-up time (TBUT), the Schirmer test under anesthesia, the corneal fluorescein staining (CFS) score, mean central corneal thickness (CCT) and mean central corneal epithelial thickness (CCET), and the two groups were compared.
A statistically significant difference was determined between the two groups at postoperative 1 month in respect of TBUT, Schirmer test, CFS score, and CCET (p < 0.01). In Group A, a statistically significant increase was determined in the TBUT and Schirmer values at 1 month postoperatively (p < 0.01, p = 0.01, respectively) and in Group B, these values were decreased compared to preoperatively (p < 0.01). The CCET was determined to be significantly thinner in Group B 1 month postoperatively (p < 0.01). A significant increase in CCT was observed in both groups at postoperative 1 week (p < 0.01) and preoperative values were reached at 1 month postoperatively.
In the patient group using sodium hyaluronate, significant differences were determined in all dry eye parameters and CCET. The use of hyaluronate sodium drops after cataract surgery was seen to improve dry eye parameters and contribute to a healthy ocular surface by ensuring continuity of the corneal epithelium.
评估白内障手术后透明质酸钠滴眼液对干眼参数及角膜上皮厚度的影响。
该研究纳入了84例行单纯超声乳化白内障吸除术的患者。A组在术后抗生素/抗炎治疗中加入0.15%透明质酸钠滴眼液。B组仅进行抗生素/抗炎治疗。在术前、术后1周和1个月时，对所有患者进行泪膜破裂时间（TBUT）、麻醉下泪液分泌试验、角膜荧光素染色（CFS）评分、平均中央角膜厚度（CCT）和平均中央角膜上皮厚度（CCET）的评估，并对两组进行比较。
两组在术后1个月时，TBUT、泪液分泌试验、CFS评分和CCET方面存在统计学显著差异（p < 0.01）。A组术后1个月时TBUT和泪液分泌试验值有统计学显著增加（分别为p < 0.01，p = 0.01），B组这些值较术前降低（p < 0.01）。术后1个月时B组的CCET明显更薄（p < 0.01）。两组术后1周时CCT均显著增加（p < 0.01），术后1个月时达到术前值。
在使用透明质酸钠的患者组中，所有干眼参数和CCET均存在显著差异。白内障手术后使用透明质酸钠滴眼液可改善干眼参数，并通过确保角膜上皮的连续性有助于形成健康的眼表。
