Lee Chia-Yi, Yang Shun-Fa, Chen Yun-Chen, Chang Chao-Kai
Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan.
Nobel Eye Institute, Taipei 10041, Taiwan.
Diagnostics (Basel). 2024 Aug 16;14(16):1796. doi: 10.3390/diagnostics14161796.
In this study, we aimed to investigate the effect of different hyaluronic acid (HA)-containing artificial tears on dry eye disease (DED) treatment in combination with intense pulsed light (IPL) therapy. A retrospective cohort study was conducted, and the participants received IPL therapy and HA-containing artificial tears. There were 42 and 40 eyes in the 0.10% and 0.15% HA groups after selection, respectively. The main outcomes were the postoperative non-invasive tear break-up time (NITBUT), Schirmer II test results, ocular surface stain, and numbers of DED-related symptoms. A generalized linear model was utilized to produce the adjusted odds ratio (aOR) and 95% confidence interval (CI) of the main outcomes between groups. At the three-month follow-up, the NITBUT was significantly higher in the 0.15% HA group ( = 0.023), and the NITBUT recovery was also significantly better in the 0.15% HA group compared to the 0.10% HA group ( = 0.039). The multiple DED-related symptoms significantly correlated with no DED symptom improvement in both the 0.10% and 0.15% HA groups (both < 0.05), while the low pre-treatment NITBUT was marginally related to no DED symptom improvement in the 0.10% HA group ( = 0.047). A low NITBUT and Schirmer II test result correlated with no DED symptom improvement in both the groups (all < 0.05). In conclusion, the application of 0.10% and 0.15% HA-containing artificial tears revealed similar effects to IPL therapy for DED.
在本研究中，我们旨在探讨不同含透明质酸（HA）的人工泪液联合强脉冲光（IPL）治疗对干眼症（DED）的疗效。进行了一项回顾性队列研究，参与者接受IPL治疗和含HA的人工泪液。入选后，0.10%HA组和0.15%HA组分别有42只眼和40只眼。主要观察指标为术后无创泪膜破裂时间（NITBUT）、Schirmer II试验结果、眼表染色以及DED相关症状的数量。采用广义线性模型得出两组主要观察指标的调整优势比（aOR）和95%置信区间（CI）。在三个月的随访中，0.15%HA组的NITBUT显著更高（P = 0.023），且0.15%HA组的NITBUT恢复情况也显著优于0.10%HA组（P = 0.039）。在0.10%HA组和0.15%HA组中，多种DED相关症状均与DED症状无改善显著相关（均P < 0.05），而在0.10%HA组中，治疗前低NITBUT与DED症状无改善有边缘相关性（P = 0.047）。两组中低NITBUT和Schirmer II试验结果均与DED症状无改善相关（均P < 0.05）。总之，应用含0.10%和0.15%HA的人工泪液治疗DED显示出与IPL治疗相似的效果。
