受体相互作用蛋白激酶 3（RIPK3）：早产儿坏死性小肠结肠炎的新生物标志物。
Receptor-interacting protein kinase-3 (RIPK3): a new biomarker for necrotising enterocolitis in preterm infants.
机构信息
Department of Neonatology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, Jiangsu Province, China.
出版信息
Pediatr Surg Int. 2024 May 2;40(1):115. doi: 10.1007/s00383-024-05697-x.
OBJECTIVE
This study aimed to evaluate the role of receptor-interacting protein kinase-3 (RIPK3) in the diagnosis, estimation of disease severity, and prognosis of premature infants with necrotising enterocolitis (NEC).
METHODS
RIPK3, lactic acid (LA), and C-reactive protein (CRP) levels were measured in the peripheral blood of 108 premature infants between 2019 and 2023, including 24 with stage II NEC, 18 with stage III NEC and 66 controls. Diagnostic values of the indicators for NEC were evaluated via receiver operating characteristic (ROC) curve analysis.
RESULTS
Plasma RIPK3 and LA levels upon NEC suspicion in neonates with stage III NEC were 32.37 ± 16.20 ng/mL. The ROC curve for the combination of RIPK3, LA, CRP for NEC diagnosis were 0.925. The time to full enteral feeding (FEFt) after recovery from NEC was different between two expression groups of plasma RIPK3 (RIPK3 < 20.06 ng/mL and RIPK3 ≥ 20.06 ng/mL).
CONCLUSION
Plasma RIPK3 can be used as a promising marker for the diagnosis and estimation of disease severity of premature infants with NEC and for the guidance on proper feeding strategies after recovery from NEC.
目的
本研究旨在评估受体相互作用蛋白激酶 3（RIPK3）在坏死性小肠结肠炎（NEC）早产儿的诊断、疾病严重程度评估和预后中的作用。
方法
在 2019 年至 2023 年期间，对 108 名早产儿的外周血进行了 RIPK3、乳酸（LA）和 C 反应蛋白（CRP）水平的测量，其中包括 24 例 2 期 NEC、18 例 3 期 NEC 和 66 例对照组。通过受试者工作特征（ROC）曲线分析评估了这些指标对 NEC 的诊断价值。
结果
怀疑患有 3 期 NEC 的新生儿出现 NEC 时，血浆 RIPK3 和 LA 水平分别为 32.37±16.20ng/mL。RIPK3、LA、CRP 联合用于 NEC 诊断的 ROC 曲线为 0.925。从 NEC 恢复后达到完全肠内喂养（FEFt）的时间在两个血浆 RIPK3 表达组（RIPK3<20.06ng/mL 和 RIPK3≥20.06ng/mL）之间存在差异。
结论
血浆 RIPK3 可作为预测 NEC 早产儿诊断和疾病严重程度的有前途的标志物，并可指导 NEC 恢复后适当的喂养策略。
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