Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.
Department of Public Health, Clinicum, University of Helsinki, Helsinki, Finland.
J Affect Disord. 2024 Aug 1;358:70-78. doi: 10.1016/j.jad.2024.04.096. Epub 2024 Apr 30.
Adolescent mental health problems impose a significant burden. Exploring evolving social environments could enhance comprehension of their impact on mental health. We aimed to depict the trajectories of the neighborhood social exposome from middle to late adolescence and assess the intricate relationship between them and late adolescent mental health.
Participants (n = 3965) from the FinnTwin12 cohort with completed questionnaires at age 17 were used. Nine mental health measures were assessed. The social exposome comprised 28 neighborhood social indicators. Trajectories of these indicators from ages 12 to 17 were summarized via latent growth curve modeling into growth factors, including baseline intercept. Mixture effects of all growth factors were assessed through quantile-based g-computation. Repeated generalized linear regressions identified significant growth factors. Sex stratification was performed.
The linear-quadratic model was the most optimal trajectory model. No mixture effect was detected. Regression models showed some growth factors saliently linked to the p-factor, internalizing problems, anxiety, hyperactivity, and aggression. The majority of them were baseline intercepts. Quadratic growth factors about mother tongues correlated with anxiety among sex-combined participants and males. The linear growth factor in the proportion of households of couples without children was associated with internalizing problems in females.
We were limited to including only neighborhood-level social exposures, and the multilevel contextual exposome situation interfered with our assessment.
Trajectories of the social neighborhood exposome modestly influenced late adolescent mental health. Tackling root causes of social inequalities through targeted programs for living conditions could improve adolescent mental health.
青少年心理健康问题带来了巨大的负担。探索不断变化的社会环境可以增强我们对其对心理健康影响的理解。我们旨在描述从中年到青春期后期邻里社会暴露组的轨迹，并评估它们与青春期后期心理健康之间的复杂关系。
使用 FinnTwin12 队列中完成了 17 岁时问卷调查的参与者（n=3965）。评估了 9 项心理健康指标。社会暴露组包括 28 个邻里社会指标。通过潜在增长曲线建模，将这些指标从 12 岁到 17 岁的轨迹概括为增长因素，包括基线截距。通过基于分位数的 g 计算评估所有增长因素的混合效应。重复广义线性回归确定了显著的增长因素。进行了性别分层。
线性二次模型是最优化的轨迹模型。未检测到混合效应。回归模型显示，一些增长因素与 p 因素、内化问题、焦虑、多动和攻击行为显著相关。其中大多数是基线截距。与母语相关的二次增长因素与男女混合参与者的焦虑有关。与无子女夫妇家庭比例的线性增长因素与女性的内化问题有关。
我们仅限于包括邻里层面的社会暴露，多层次的上下文暴露组情况干扰了我们的评估。
社会邻里暴露组的轨迹对青春期后期的心理健康有一定的影响。通过针对生活条件的有针对性计划解决社会不平等的根本原因，可以改善青少年的心理健康。
