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全髋关节置换术与教育和运动:266 例髋骨关节炎患者的倾向匹配分析。

Total Hip Arthroplasty Versus Education and Exercise: A Propensity-Matched Analysis of 266 Patients Who Have Hip Osteoarthritis.

机构信息

Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Toronto, Canada; Department of Sports Science and Clinical Biomechanics, Center for Muscle and Joint Health, University of Southern Denmark, Odense, Denmark.

Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Toronto, Canada; Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada; Faculty of Medicine, Department of Surgery, University of Toronto, Toronto, Ontario, Canada.

出版信息

J Arthroplasty. 2024 Sep;39(9S2):S261-S269. doi: 10.1016/j.arth.2024.04.072. Epub 2024 Apr 30.

Abstract

BACKGROUND

Total hip arthroplasty (THA) for osteoarthritis (OA) is a major health system cost. Education and exercise (Edu + Ex) programs may reduce the number of THAs needed, but supporting data are limited. This study aimed to estimate the treatment effect of THA versus Edu + Ex on pain, function, and quality of life outcomes 3 and 12 months after treatment initiation for hip OA.

METHODS

Patients who had hip OA who underwent THA or an Edu + Ex program were included in this propensity-matched study. In 778 patients (Edu + Ex, n = 303; THA, n = 475), propensity scores were based on pretreatment characteristics, and patients were matched on a 1:1 ratio. Between-group treatment effects (pain, function, and quality of life) were estimated as the mean difference (MD) in change from pretreatment to 3-month and 12-month follow-up using linear mixed models.

RESULTS

The matched sample consisted of 266 patients (Edu + Ex, n = 133; THA, n = 133) who were balanced on all pretreatment characteristics except opioid use. At 12-month follow-up, THA resulted in significantly greater improvements in pain (MD 35.4; 95% confidence interval [CI] 31.4 to 39.4), function (MD 30.5; 95% CI 26.3 to 34.7), and quality of life (MD 33.6; 95% CI 28.8 to 38.4). Between 17% and 30% of patients receiving Edu + Ex experienced a surgical threshold for clinically meaningful improvement in outcomes, compared to 84% and 90% of THA patients.

CONCLUSIONS

A THA provides greater improvements in pain, function, and quality of life. A notable proportion of Edu + Ex patients had clinically meaningful improvements, suggesting Edu + Ex may result in THA deferral in some patients, but confirmatory trials are needed.

摘要

背景

全髋关节置换术(THA)治疗骨关节炎(OA)是医疗系统的一项重大支出。教育和锻炼(Edu + Ex)项目可能会减少需要进行 THA 的数量,但目前相关支持数据有限。本研究旨在评估与 Edu + Ex 相比,THA 在治疗启动后 3 个月和 12 个月时对髋部 OA 患者疼痛、功能和生活质量的治疗效果。

方法

本研究纳入了接受 THA 或 Edu + Ex 治疗的髋部 OA 患者。在 778 例患者中(Edu + Ex 组 303 例,THA 组 475 例),基于治疗前特征进行倾向评分匹配,以 1:1 的比例进行患者匹配。使用线性混合模型估计组间治疗效果(疼痛、功能和生活质量),其表现为从治疗前到 3 个月和 12 个月随访的变化的平均差值(MD)。

结果

匹配后的样本包含 266 例患者(Edu + Ex 组 133 例,THA 组 133 例),除了阿片类药物的使用外,所有治疗前的特征都得到了很好的平衡。在 12 个月的随访中,THA 组在疼痛(MD 35.4;95%置信区间 [CI] 31.4 至 39.4)、功能(MD 30.5;95% CI 26.3 至 34.7)和生活质量(MD 33.6;95% CI 28.8 至 38.4)方面的改善明显更大。与接受 Edu + Ex 的患者相比,17%至 30%的患者经历了手术阈值,以实现结局的临床意义改善,而 THA 组的这一比例为 84%和 90%。

结论

THA 可明显改善疼痛、功能和生活质量。Edu + Ex 的相当一部分患者出现了具有临床意义的改善,这表明 Edu + Ex 可能会使一些患者延迟进行 THA,但仍需要进行验证性试验。

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