Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA; Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany.
Magnetoencephalography Core, National Institute of Mental Health, Bethesda, MD, USA.
Neurosci Biobehav Rev. 2024 Jul;162:105693. doi: 10.1016/j.neubiorev.2024.105693. Epub 2024 Apr 30.
Music and ketamine are both known to affect therapeutic outcomes, but few studies have investigated their co-administration. This scoping review describes the existing literature on the joint use of music and ketamine-or esketamine (the S(+) enantiomer of ketamine)-in humans. The review considers that extant studies have explored the intersection of ketamine/esketamine and music in healthy volunteers and in patients of various age groups, at different dosages, through different treatment processes, and have varied the sequence of playing music relative to ketamine/esketamine administration. Studies investigating the use of music during ketamine anesthesia are also included in the review because anesthesia and sedation were the early drivers of ketamine use. Studies pertaining to recreational ketamine use were omitted. The review was limited to articles published in the English language but not restricted by publication year. To the best of our knowledge, this scoping review is the first comprehensive exploration of the interplay between music and ketamine/esketamine and offers valuable insights to researchers interested in designing future studies.
音乐和氯胺酮都已知会影响治疗效果，但很少有研究调查它们的联合使用。本范围综述描述了现有关于人类联合使用音乐和氯胺酮或艾司氯胺酮（氯胺酮的 S(+)对映体）的文献。综述认为，现有研究已经在健康志愿者和不同年龄组的患者中，通过不同的治疗过程，在不同的剂量下，以及在播放音乐与给予氯胺酮/艾司氯胺酮的顺序上，探索了氯胺酮/艾司氯胺酮与音乐的交叉点。本综述还包括了在氯胺酮麻醉期间使用音乐的研究，因为麻醉和镇静是氯胺酮早期应用的驱动因素。与娱乐性氯胺酮使用相关的研究被排除在外。本综述仅限于发表在英语中的文章，但不受出版年份的限制。据我们所知，这篇范围综述是对音乐和氯胺酮/艾司氯胺酮相互作用的首次全面探索，为有兴趣设计未来研究的研究人员提供了有价值的见解。
