Department of Restorative Dentistry, College of Dentistry, University of Ha'il, Ha'il 55473, Saudi Arabia.
Department of Dentistry, LLRM Medical College, CCS University Meerut, Meerut, 250002, UP, India.
Ir J Med Sci. 2024 Aug;193(4):1949-1955. doi: 10.1007/s11845-024-03695-5. Epub 2024 May 3.
Cytokines, including interleukin-12 (IL-12), are proteins that regulate cell survival, proliferation, differentiation, and function. IL-12 is a heterodimeric proinflammatory cytokine. It possesses tumoricidal properties and promotes M1 macrophage polarization and IFN-γ production by T helper (Th1) cells, which in turn stimulates the antitumor cytotoxic cluster of eight positive (CD8+) and natural killer cells, therefore activating an effector immune response against tumor cells.
Herein, the IL-2 levels of 60 patients with generalized chronic periodontitis (GCP) were assessed. Plaque index, gingival index, pocket probing depth, bleeding on probing percentage (BOP %), and clinical attachment loss were the clinical indicators reported.
Patients with GCP in the pretreatment group had substantially lower mean IL-12 levels than those in the post-treatment group. Short-term, nonsurgical treatment (NST) considerably improved periodontal indices and increased IL-12 levels, thereby reducing oral cancer risk.
NST is a cost-effective and accessible cancer prevention procedure for general dentists.
细胞因子，包括白细胞介素-12（IL-12），是调节细胞存活、增殖、分化和功能的蛋白质。IL-12 是一种异源二聚体细胞因子。它具有杀肿瘤特性，并促进辅助性 T（Th1）细胞的 M1 巨噬细胞极化和 IFN-γ产生，进而刺激抗肿瘤细胞毒性 8 因子阳性（CD8+）和自然杀伤细胞，从而激活针对肿瘤细胞的效应免疫反应。
在此，评估了 60 例广泛性慢性牙周炎（GCP）患者的 IL-2 水平。报道的临床指标包括菌斑指数、牙龈指数、牙周袋探诊深度、探诊出血百分比（BOP%）和临床附着丧失。
预处理组的 GCP 患者的平均 IL-12 水平明显低于治疗后组。短期非手术治疗（NST）显著改善牙周指数并增加 IL-12 水平，从而降低口腔癌风险。
NST 是普通牙医进行成本效益高且易于获得的癌症预防措施。
