不同牙周状况龈沟液和牙龈组织中内脂素的表达：一项横断面研究。

Expression of visfatin in gingival crevicular fluid and gingival tissues in different periodontal conditions: a cross-sectional study.

机构信息

Fujian Key Laboratory of Oral Diseases & Fujian Provincial Engineering Research Center of Oral Biomaterial & Stomatological Key Lab of Fujian College and University, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, China.

Institute of Stomatology & Research Center of Dental and Craniofacial Implants, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, China.

出版信息

BMC Oral Health. 2024 May 2;24(1):514. doi: 10.1186/s12903-024-04299-2.

DOI:10.1186/s12903-024-04299-2

PMID:38698364

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11064311/

Abstract

BACKGROUND

Studies have shown that visfatin is an inflammatory factor closely related to periodontitis. We examined the levels of visfatin in gingival crevicular fluid (GCF) and gingival tissues under different periodontal conditions, in order to provide more theoretical basis for exploring the role of visfatin in the pathogenesis of periodontitis.

METHODS

We enrolled 87 subjects, with 43 in the chronic periodontitis (CP) group, 21 in the chronic gingivitis (CG) group, and 23 in the periodontal health (PH) group. Periodontal indexes (PD, AL, PLI, and BI) were recorded. GCF samples were collected for visfatin quantification, and gingival tissues were assessed via immunohistochemical staining.

RESULTS

Visfatin levels in GCF decreased sequentially from CP to CG and PH groups, with statistically significant differences (P < 0.05). The CP group exhibited the highest visfatin levels, while the PH group had the lowest. Gingival tissues showed a similar trend, with significant differences between groups (P < 0.001). Periodontal indexes were positively correlated with visfatin levels in both GCF and gingival tissues (P < 0.001). A strong positive correlation was observed between visfatin levels in GCF and gingival tissues (rs = 0.772, P < 0.001).

CONCLUSION

Greater periodontal destruction corresponded to higher visfatin levels in GCF and gingival tissues, indicating their potential collaboration in damaging periodontal tissues. Visfatin emerges as a promising biomarker for periodontitis and may play a role in its pathogenesis.

摘要

背景

研究表明内脂素是一种与牙周炎密切相关的炎症因子。我们检测了不同牙周状况下龈沟液（GCF）和牙龈组织中内脂素的水平，以期为探讨内脂素在牙周炎发病机制中的作用提供更多的理论依据。

方法

共纳入 87 例受试者，其中慢性牙周炎（CP）组 43 例，慢性龈炎（CG）组 21 例，牙周健康（PH）组 23 例。记录牙周指数（PD、AL、PLI 和 BI）。采集 GCF 样本用于内脂素定量检测，采用免疫组化染色法评估牙龈组织。

结果

GCF 中的内脂素水平从 CP 组到 CG 组和 PH 组依次降低，差异有统计学意义（P<0.05）。CP 组的内脂素水平最高，PH 组最低。牙龈组织也呈现出相似的趋势，组间差异有统计学意义（P<0.001）。牙周指数与 GCF 和牙龈组织中的内脂素水平呈正相关（P<0.001）。GCF 和牙龈组织中的内脂素水平之间存在很强的正相关（rs=0.772，P<0.001）。