Student Research Committee, School of Dentistry, Arak University of Medical Sciences, Arak, Iran.
Department of Periodontics, School of Dentistry, Arak University of Medical Science, Arak, Iran.
Clin Rheumatol. 2019 Nov;38(11):3139-3143. doi: 10.1007/s10067-019-04708-w. Epub 2019 Aug 1.
Visfatin is an adipokine and has a crucial role in pro-inflammatory response. The aim of this study was investigating the visfatin levels of gingival crevicular fluid (GCF) in patients with systemic lupus erythematosus (SLE) and chronic periodontitis and healthy subjects.
Sixty non-obese females were selected based on their clinical parameters into four groups: 15 healthy subjects (H-H), 15 systemically healthy individuals with chronic periodontitis (H-CP), 15 SLE patient with CP (SLE-CP), and 15 SLE patients without CP (SLE-H). GCF samples were collected to estimate the levels of visfatin using enzyme-linked immunosorbent assay (ELISA).
Investigating the amount of visfatin in the GCF showed that there is a significant difference between visfatin amount of GCF in SLE patients and chronic periodontitis (L-CP) in comparison with other groups (P < 0.001).
Visfatin levels have correlated positively with all the clinical periodontal parameters and its levels in (L-CP) group are highest in comparative with other groups. This finding suggests visfatin has a possible role in association between these two inflammatory conditions. Key Point • Visfatin in systemic lupus erythematosus.
内脂素是一种脂肪细胞因子，在促炎反应中起关键作用。本研究旨在探讨系统性红斑狼疮（SLE）和慢性牙周炎患者龈沟液（GCF）中内脂素水平。
根据临床参数，选择 60 名非肥胖女性分为 4 组：15 名健康受试者（H-H）、15 名系统性健康伴慢性牙周炎患者（H-CP）、15 名伴 CP 的 SLE 患者（SLE-CP）和 15 名无 CP 的 SLE 患者（SLE-H）。收集 GCF 样本，使用酶联免疫吸附试验（ELISA）来评估内脂素水平。
研究 GCF 中的内脂素含量表明，SLE 患者和慢性牙周炎（L-CP）患者 GCF 中的内脂素含量与其他组之间存在显著差异（P<0.001）。
内脂素水平与所有临床牙周参数呈正相关，在（L-CP）组中其水平与其他组相比最高。这一发现表明，内脂素可能在这两种炎症状态之间存在关联。
系统性红斑狼疮中的内脂素。
