Gazi University, Faculty of Dentistry, Department of Periodontology, Ankara, Turkey.
Gazi University, Faculty of Dentistry, Department of Microbiology, Ankara, Turkey.
J Appl Oral Sci. 2019 Jul 29;27:e20180365. doi: 10.1590/1678-7757-2018-0365.
Visfatin is an adipokine that plays an important role in immune functions as a growth factor, enzyme, and pro-inflammatory mediator. We aimed to determine the levels of visfatin, interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) in gingival crevicular fluid (GCF) in both obese/non-obese patients, with/without generalized chronic periodontitis (GCP).
Patients were categorized as obese (O) (n=31) or non-obese (nO) (n=19). Groups were divided into four subgroups according to periodontal conditions: (1) periodontally healthy without obesity (nO-Ctrl); (2) GCP without obesity (nO-CP); (3) periodontally healthy with obesity (O-Ctrl); and (4) GCP with obesity (O-CP). Demographic variables, anthropometric and laboratory data were recorded. Periodontal parameters were measured at baseline and 3rd months after either non-surgical periodontal treatment or calorie -restricted diet therapy. At the same time, GCF samples were taken from patients to analyze TNF-alpha, IL-6,and visfatin levels.
Periodontal parameters were significantly higher in the O group than in the nO group (P<0.05). IL-6 levels were higher in the O group than in the nO group (P<0.001). The visfatin levels of the obese patients were reduceddecreased following the treatments (P<0.05). Cholesterol levels were higher in the O group than in the nO groups (P<0.05). IL-6 levels were higher in O-CP and O-Ctrl groups than in the nO-Ctrl group (P<0.05). Compared to the other groups, visfatin levels were significantly higher in the O-CP group but decreased following treatment (P<0.05).
Our findings suggest that visfatin and IL-6 levels in GCF are associated with the pathogenesis of obesity and periodontitis. Within the limits of this study, we considered that there might be an association between the lipid profile and periodontitis on systemically healthy individuals.
内脂素是一种脂肪细胞因子，作为生长因子、酶和促炎介质，在免疫功能中发挥重要作用。我们旨在确定龈沟液（GCF）中内脂素、白细胞介素-6（IL-6）和肿瘤坏死因子-α（TNF-α）在肥胖/非肥胖患者以及伴或不伴广泛性慢性牙周炎（GCP）患者中的水平。
将患者分为肥胖（O）组（n=31）或非肥胖（nO）组（n=19）。根据牙周状况将两组分为四个亚组：（1）无肥胖的牙周健康（nO-Ctrl）；（2）无肥胖的 GCP（nO-CP）；（3）肥胖的牙周健康（O-Ctrl）；（4）肥胖的 GCP（O-CP）。记录人口统计学变量、人体测量学和实验室数据。在非手术牙周治疗或限制热量饮食治疗后基线和第 3 个月测量牙周参数。同时，从患者中采集龈沟液样本，分析 TNF-α、IL-6 和内脂素水平。
O 组的牙周参数明显高于 nO 组（P<0.05）。O 组的 IL-6 水平高于 nO 组（P<0.001）。肥胖患者的内脂素水平在治疗后降低（P<0.05）。O 组的胆固醇水平高于 nO 组（P<0.05）。O-CP 和 O-Ctrl 组的 IL-6 水平高于 nO-Ctrl 组（P<0.05）。与其他组相比，O-CP 组的内脂素水平显著升高，但治疗后降低（P<0.05）。
我们的研究结果表明，GCF 中的内脂素和 IL-6 水平与肥胖和牙周炎的发病机制有关。在本研究的范围内，我们认为在系统健康个体中，脂质谱与牙周炎之间可能存在关联。
