Djiwa Toukilnan, Koui B B S, Aman N A, Coulibaly Z I, Kouyate M, Kouame K E
Department of Pathological Anatomy, Teaching Hospital of Lomé, BP 1515, Lomé, Togo.
Department of Pathological Anatomy, Teaching Hospital of Treichville, Abidjan, Ivory Coast.
J Med Case Rep. 2024 May 3;18(1):219. doi: 10.1186/s13256-024-04533-z.
Mantle cell lymphoma is a rare lymphoma of the gastrointestinal tract that may present as multiple lymphomatous polyposis. We report a case of lymphomatous polyposis with a review of the literature.
A 56-year-old man of Black ethnicity and Ivorian nationality with no relevant past medical history, consulted for a sudden onset symptoms of gastrointestinal obstruction, which evolved over 2 days. Macroscopic examination revealed the presence of multiple polyploid formations of the colonic mucosa. Histology showed diffuse lymphomatous proliferation of submucosa consisting off small lymphoid cells with a hyperchromatic crenelated nucleus, suggesting lymphomatous polyposis. Immunohistochemical examination showed expression by the tumor cells of antibodies to CD20, CD5, Bcl2, and cyclin D1. They did not express antibodies to CD10 and CD23. The Ki67 proliferation index was 25%. We have thus retained the diagnosis of mantle cell lymphomatous polyposis.
Multiple lymphomatous polyposis is a rare entity characterized by the presence of numerous gastrointestinal polyploid lesions sometimes involving several segments of the gastrointestinal tract. Typical lymphoma presenting as lymphomatous polyposis is mantle cell lymphoma; although, other tumors may have this aspect.
套细胞淋巴瘤是一种罕见的胃肠道淋巴瘤，可表现为多发性淋巴瘤性息肉病。我们报告一例淋巴瘤性息肉病病例并对文献进行综述。
一名56岁的黑人男性，具有科特迪瓦国籍，既往无相关病史，因突发肠梗阻症状前来就诊，症状持续2天。宏观检查发现结肠黏膜存在多个多倍体形成物。组织学显示黏膜下层弥漫性淋巴瘤样增殖，由小淋巴细胞组成，细胞核呈深染的锯齿状，提示淋巴瘤性息肉病。免疫组化检查显示肿瘤细胞表达CD20、CD5、Bcl2和细胞周期蛋白D1抗体。它们不表达CD10和CD23抗体。Ki67增殖指数为25%。因此，我们诊断为套细胞淋巴瘤性息肉病。
多发性淋巴瘤性息肉病是一种罕见的疾病，其特征是存在大量胃肠道多倍体病变，有时累及胃肠道的多个节段。表现为淋巴瘤性息肉病的典型淋巴瘤是套细胞淋巴瘤；不过，其他肿瘤也可能有这种表现。
