ICFO-Institut de Ciencies Fotoniques, The Barcelona Institute of Science and Technology, Castelldefels, Barcelona, Spain.
ICFO-Institut de Ciencies Fotoniques, The Barcelona Institute of Science and Technology, Castelldefels, Barcelona, Spain.
Biophys J. 2024 Jun 18;123(12):1531-1541. doi: 10.1016/j.bpj.2024.04.031. Epub 2024 May 2.
The emergence of phase separation phenomena among macromolecules has identified biomolecular condensates as fundamental cellular organizers. These condensates concentrate specific components and accelerate biochemical reactions without relying on membrane boundaries. Although extensive studies have revealed a large variety of nuclear and cytosolic membraneless organelles, we are witnessing a surge in the exploration of protein condensates associated with the membranes of the secretory pathway, such as the endoplasmic reticulum and the Golgi apparatus. This review focuses on protein condensates in the secretory pathway and discusses their impact on the organization and functions of this cellular process. Moreover, we explore the modes of condensate-membrane association and the biophysical and cellular consequences of protein condensate interactions with secretory pathway membranes.
相分离现象的出现使生物大分子凝聚物成为基本的细胞组织者。这些凝聚物浓缩特定的成分并加速生化反应，而无需依赖于膜边界。尽管广泛的研究揭示了大量的核和胞质无膜细胞器，但我们正在见证与分泌途径的膜相关的蛋白质凝聚物的探索激增，如内质网和高尔基体。本综述重点介绍分泌途径中的蛋白质凝聚物，并讨论它们对细胞过程的组织和功能的影响。此外，我们探讨了凝聚物与膜的结合方式以及蛋白质凝聚物与分泌途径膜相互作用的生物物理和细胞后果。
