Kong Yifan, Wei Xiaohong, Zhang Di, Lin Hongyuan, Peng Mengqi, Shang Hongcai
Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.
Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China.
Heliyon. 2024 Apr 21;10(9):e29926. doi: 10.1016/j.heliyon.2024.e29926. eCollection 2024 May 15.
This study aimed to evaluate the global research trend in the prevention and treatment of cardiotoxicity caused by anthracyclines from 2000 to 2023, and to explore international cooperation, research hotspots, and frontier trends.
The articles on the prevention and treatment of anthracycline-induced cardiotoxicity published from 2000 to 2023 were searched by Web of Science. The bibliometrics software CiteSpace was used for visual analysis of countries, institutions, journals, authors, cited authors, cited references, and keywords.
This study analyzed the current status of global research on the prevention and treatment of cardiotoxicity caused by anthracyclines. A total of 3,669 papers were searched and 851 studies were included. The number of publications increased gradually throughout the years. (15) is the journal with the most publications. (547) ranked first among cited journals. In this field, the country with the most publications is the United States (229), and the institution with the most publications is Charles Univ Prague (18). In the analysis of the authors, Tomas S (10) ranked first. Cardinale D (262) ranked first among cited authors. In the ranking of cited literature frequency, the article ranked first is "Early detection of anthracycline cardiotoxicity and improvement with heart failure therapy" (121). The keywords "heart failure" (215) and "oxidative stress" (212) were the most frequent. "Enalapril", "inflammation", "cell death", "NF-κB" and "Nrf2" were the advanced research contents in 2019-2023.
This study provided valuable information for cardio-oncology researchers to identify potential collaborators and institutions, discover hot topics, and explore new research directions. The prevention and treatment of anthracycline-induced cardiotoxicity focuses on early detection and timely treatment. The results of the current clinical studies on the treatment of anthracycline-induced cardiotoxicity are contradictory, and more studies are needed to provide more reliable clinical evidence in the future.
本研究旨在评估2000年至2023年蒽环类药物所致心脏毒性防治的全球研究趋势，并探讨国际合作、研究热点及前沿趋势。
通过Web of Science检索2000年至2023年发表的关于蒽环类药物所致心脏毒性防治的文章。使用文献计量学软件CiteSpace对国家、机构、期刊、作者、被引作者、被引参考文献和关键词进行可视化分析。
本研究分析了全球蒽环类药物所致心脏毒性防治研究现状。共检索到3669篇论文，纳入851项研究。历年发表数量呈逐渐增加趋势。（15）是发表论文最多的期刊。（547）在被引期刊中排名第一。在该领域，发表论文最多的国家是美国（229篇），发表论文最多的机构是查尔斯大学布拉格分校（18篇）。在作者分析中，托马斯·S（10篇）排名第一。卡尔迪纳莱·D（262次）在被引作者中排名第一。在被引文献频次排名中，排名第一的文章是《蒽环类药物心脏毒性的早期检测及心力衰竭治疗的改善》（121次）。关键词“心力衰竭”（215次）和“氧化应激”（212次）出现频率最高。“依那普利”“炎症”“细胞死亡”“NF-κB”和“Nrf2”是2019 - 2023年的前沿研究内容。
本研究为心脏肿瘤学研究人员识别潜在合作者和机构、发现热点话题及探索新的研究方向提供了有价值的信息。蒽环类药物所致心脏毒性的防治重点在于早期检测和及时治疗。目前关于蒽环类药物所致心脏毒性治疗的临床研究结果相互矛盾，未来需要更多研究提供更可靠的临床证据。
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