全球心血管肿瘤注册研究（G-COR）：一项多中心全球倡议的注册设计、主要目标和未来展望。
Global Cardio Oncology Registry (G-COR): Registry Design, Primary Objectives, and Future Perspectives of a Multicenter Global Initiative.
机构信息
Department of Cardiology, University Medical Centre Utrecht, The Netherlands (A.J.T.).
Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic Foundation, OH (R.M., V.M., P.C.).
出版信息
Circ Cardiovasc Qual Outcomes. 2023 Oct;16(10):e009905. doi: 10.1161/CIRCOUTCOMES.123.009905. Epub 2023 Sep 13.
BACKGROUND
Global collaboration in cardio-oncology is needed to understand the prevalence of cancer therapy-related cardiovascular toxicity in different risk groups, practice settings, and geographic locations. There are limited data on the socioeconomic and racial/ethnic disparities that may impact access to care and outcomes. To address these gaps, we established the Global Cardio-Oncology Registry, a multinational, multicenter prospective registry.
METHODS
We assembled cardiologists and oncologists from academic and community settings to collaborate in the first Global Cardio-Oncology Registry. Subsequently, a survey for site resources, demographics, and intention to participate was conducted. We designed an online data platform to facilitate this global initiative.
RESULTS
A total of 119 sites responded to an online questionnaire on their practices and main goals of the registry: 49 US sites from 23 states and 70 international sites from 5 continents indicated a willingness to participate in the Global Cardio-Oncology Registry. Sites were more commonly led by cardiologists (85/119; 72%) and were more often university/teaching (81/119; 68%) than community based (38/119; 32%). The average number of cardio-oncology patients treated per month was 80 per site. The top 3 Global Cardio-Oncology Registry priorities in cardio-oncology care were breast cancer, hematologic malignancies, and patients treated with immune checkpoint inhibitors. Executive and scientific committees and specific committees were established. A pilot phase for breast cancer using Research Electronic Data Capture Cloud platform recently started patient enrollment.
CONCLUSIONS
We present the structure for a global collaboration. Information derived from the Global Cardio-Oncology Registry will help understand the risk factors impacting cancer therapy-related cardiovascular toxicity in different geographic locations and therefore contribute to reduce access gaps in cardio-oncology care. Risk calculators will be prospectively derived and validated.
背景
为了了解不同风险群体、实践环境和地理位置中癌症治疗相关心血管毒性的流行情况，需要开展全球协作的心血管肿瘤学。关于可能影响护理和结局的社会经济及种族差异的数据有限。为了解决这些差距，我们建立了全球心血管肿瘤学注册中心，这是一个多国家、多中心的前瞻性注册中心。
方法
我们召集了来自学术和社区环境的心脏病专家和肿瘤学家，共同参与了首个全球心血管肿瘤学注册中心。随后，我们进行了一项关于站点资源、人口统计学和参与意向的调查。我们设计了一个在线数据平台来推动这一全球计划。
结果
共有 119 个站点对其实践和注册中心的主要目标回复了在线问卷：来自 23 个州的 49 个美国站点和来自 5 大洲的 70 个国际站点表示愿意参与全球心血管肿瘤学注册中心。站点通常由心脏病专家领导（119/119；72%），比社区站点（119/119；32%）更常为大学/教学医院（81/119；68%）。每个站点每月治疗的心血管肿瘤患者平均数量为 80 人。心血管肿瘤学护理方面的全球心血管肿瘤学注册中心的前 3 个优先事项是乳腺癌、血液恶性肿瘤和接受免疫检查点抑制剂治疗的患者。成立了执行和科学委员会以及特定委员会。最近，使用 Research Electronic Data Capture Cloud 平台开始对乳腺癌进行了试点阶段的患者入组。
结论
我们提出了一个全球协作的结构。全球心血管肿瘤学注册中心获得的信息将有助于了解不同地理位置中影响癌症治疗相关心血管毒性的风险因素，从而有助于减少心血管肿瘤学护理方面的获取差距。风险计算器将被前瞻性地推导和验证。
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