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用于穿孔修复的仿生聚合物的密封效果、射线不透性及表面形貌评估

Assessment of sealing efficacy, radiopacity, and surface topography of a bioinspired polymer for perforation repair.

作者信息

Rao Lakshmi Nidhi, Shetty Aditya, Dsouza Neevan, Shetty Heeresh

机构信息

Department of Conservative Dentistry and Endodontics, AB Shetty Memorial Institute of Dental Sciences, Nitte (Deemed to be University), Mangalore, Karnataka, India.

Department of Biostatistics, K S Hegde Medical Academy, Nitte (Deemed to be University), Mangalore, Karnataka, India.

出版信息

PeerJ. 2024 Apr 29;12:e17237. doi: 10.7717/peerj.17237. eCollection 2024.

DOI:10.7717/peerj.17237
PMID:38699192
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11064857/
Abstract

BACKGROUND

Root perforation repair presents a significant challenge in dentistry due to inherent limitations of existing materials. This study explored the potential of a novel polydopamine-based composite as a root repair material by evaluating its sealing efficacy, radiopacity, and surface topography.

METHODS

Confocal microscopy assessed sealing ability, comparing the polydopamine-based composite to the gold standard, mineral trioxide aggregate (MTA). Radiopacity was evaluated using the aluminium step wedge technique conforming to ISO standards. Surface roughness analysis utilized atomic force microscopy (AFM), while field emission scanning electron microscopy (FESEM) visualized morphology.

RESULTS

The polydopamine-based composite exhibited significantly superior sealing efficacy compared to MTA ( < 0.001). Radiopacity reached 3 mm aluminium equivalent, exceeding minimum clinical requirements. AFM analysis revealed a smooth surface topography, and FESEM confirmed successful composite synthesis.

CONCLUSION

This study demonstrates promising properties of the polydopamine-based composite for root perforation repair, including superior sealing efficacy, clinically relevant radiopacity, and smooth surface topography. Further investigation is warranted to assess its clinical viability and potential translation to endodontic practice.

摘要

背景

由于现有材料存在固有限制，牙根穿孔修复在牙科领域是一项重大挑战。本研究通过评估一种新型聚多巴胺基复合材料的封闭效果、射线不透性和表面形貌，探索其作为牙根修复材料的潜力。

方法

共聚焦显微镜评估封闭能力，将聚多巴胺基复合材料与金标准材料三氧化矿物凝聚体（MTA）进行比较。使用符合ISO标准的铝阶梯楔技术评估射线不透性。表面粗糙度分析采用原子力显微镜（AFM），场发射扫描电子显微镜（FESEM）观察形态。

结果

与MTA相比，聚多巴胺基复合材料表现出显著优越的封闭效果（<0.001）。射线不透性达到3毫米铝当量，超过了最低临床要求。AFM分析显示表面形貌光滑，FESEM证实复合材料合成成功。

结论

本研究证明了聚多巴胺基复合材料用于牙根穿孔修复具有良好的性能，包括优越的封闭效果、临床相关的射线不透性和光滑的表面形貌。有必要进一步研究以评估其临床可行性以及在牙髓治疗实践中的潜在应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e7c/11064857/0d8c60c3d87d/peerj-12-17237-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e7c/11064857/4c43d0aa4170/peerj-12-17237-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e7c/11064857/f4ff21a7e021/peerj-12-17237-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e7c/11064857/4ab3e78fcfae/peerj-12-17237-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e7c/11064857/a488384368fb/peerj-12-17237-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e7c/11064857/90d560e52944/peerj-12-17237-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e7c/11064857/5bb424b43a35/peerj-12-17237-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e7c/11064857/272d568d8770/peerj-12-17237-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e7c/11064857/cdb0edd81655/peerj-12-17237-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e7c/11064857/0d8c60c3d87d/peerj-12-17237-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e7c/11064857/4c43d0aa4170/peerj-12-17237-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e7c/11064857/f4ff21a7e021/peerj-12-17237-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e7c/11064857/4ab3e78fcfae/peerj-12-17237-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e7c/11064857/a488384368fb/peerj-12-17237-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e7c/11064857/90d560e52944/peerj-12-17237-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e7c/11064857/5bb424b43a35/peerj-12-17237-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e7c/11064857/272d568d8770/peerj-12-17237-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e7c/11064857/cdb0edd81655/peerj-12-17237-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e7c/11064857/0d8c60c3d87d/peerj-12-17237-g009.jpg

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