Yan Juncheng, Wang Luoyu, Pan Lei, Ye Haiqi, Zhu Xiaofen, Feng Qi, Ding Zhongxiang, Ge Xiuhong, Shi Lei
Department of Rehabilitation, Hangzhou First People's Hospital, Hangzhou, China.
Department of Radiology, Hangzhou First People's Hospital, Hangzhou, China.
Front Hum Neurosci. 2024 Apr 17;18:1349186. doi: 10.3389/fnhum.2024.1349186. eCollection 2024.
This study aimed to explore the risk factors and potential causes of unilateral classical or idiopathic trigeminal neuralgia (C-ITN) by comparing patients and healthy controls (HCs) with neurovascular compression (NVC) using machine learning (ML).
A total of 84 C-ITN patients and 78 age- and sex-matched HCs were enrolled. We assessed the trigeminal pons angle and identified the compressing vessels and their location and severity. Machine learning was employed to analyze the cisternal segment of the trigeminal nerve (CN V).
Among the C-ITN patients, 53 had NVC on the unaffected side, while 25 HCs exhibited bilateral NVC, and 24 HCs showed unilateral NVC. By comparing the cisternal segment of CN V between C-ITN patients on the affected side and HCs with NVC, we identified the side of NVC, the compressing vessel, and certain texture features as risk factors for C-ITN. Additionally, four texture features differed in the structure of the cisternal segment of CN V between C-ITN patients on the unaffected side and HCs with NVC.
Our findings suggest that the side of NVC, the compressing vessel, and the microstructure of the cisternal segment of CN V are associated with the risk of C-ITN. Furthermore, microstructural changes observed in the cisternal segment of CN V on the unaffected side of C-ITN patients with NVC indicate possible indirect effects on the CN V to some extent.
本研究旨在通过使用机器学习（ML）比较患有神经血管压迫（NVC）的三叉神经痛患者和健康对照（HCs），探索单侧典型或特发性三叉神经痛（C-ITN）的危险因素和潜在病因。
共纳入84例C-ITN患者和78例年龄及性别匹配的HCs。我们评估了三叉神经脑桥角，确定了压迫血管及其位置和严重程度。采用机器学习分析三叉神经（CN V）的脑池段。
在C-ITN患者中，53例在未受影响侧有NVC，而25例HCs表现为双侧NVC，24例HCs表现为单侧NVC。通过比较患侧C-ITN患者和有NVC的HCs之间CN V的脑池段，我们确定了NVC的侧别、压迫血管和某些纹理特征为C-ITN的危险因素。此外，未受影响侧的C-ITN患者和有NVC的HCs之间，CN V脑池段结构的四个纹理特征存在差异。
我们的研究结果表明，NVC的侧别、压迫血管和CN V脑池段的微观结构与C-ITN的风险相关。此外，在有NVC的C-ITN患者未受影响侧的CN V脑池段观察到的微观结构变化表明，在一定程度上可能对CN V有间接影响。
