血浆可溶性细胞间黏附分子-1和可溶性P-选择素对急性呼吸窘迫综合征患者死亡风险的预测价值
Predictive value of plasma sICAM-1 and sP-Selectins in the risk of death in patients with acute respiratory distress syndrome.
作者信息
Jing Pan, Wu Chaomin, Du Chunling, Zhou Lei, Gu Liang
机构信息
Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University, Department of Pulmonary and Critical Care Medicine, Shanghai City, China.
出版信息
J Med Biochem. 2024 Apr 23;43(2):209-218. doi: 10.5937/jomb0-45340.
BACKGROUND
To evaluate the predictive value of sICAM-1 and sP-Selectins in the risk of death in a prospective cohort of adult acute respiratory distress syndrome (ARDS).
METHODS
Adult ARDS patients were included. Plasma sICAM-1, sP-Selectins, and inflammatory cytokines (TNF-α, IL-1b, IL-6, IL-8, and IL-17A) were detected in ARDS subjects. The correlation between different factors and the potential of sICAM-1 and sP-Selectins as endothelial markers to predict the risk of deathfrom ARDS was analyzed.
背景
评估可溶性细胞间黏附分子-1（sICAM-1）和可溶性P-选择素（sP-选择素）对成人急性呼吸窘迫综合征（ARDS）前瞻性队列中死亡风险的预测价值。
方法
纳入成年ARDS患者。检测ARDS受试者血浆中的sICAM-1、sP-选择素和炎性细胞因子（肿瘤坏死因子-α、白细胞介素-1β、白细胞介素-6、白细胞介素-8和白细胞介素-17A）。分析不同因素之间的相关性以及sICAM-1和sP-选择素作为内皮标志物预测ARDS死亡风险的潜力。
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