Du Meng, Jia Haoran, Zhao Tingting, Liu Ye, Wang Dexing, Wang Weiwei
Capital Medical University, Baoding Hospital of Beijing Children's Hospital, Neonatology, Baoding, China.
Capital Medical University, Baoding Hospital of Beijing Children's Hospital, Pediatrics, China.
J Med Biochem. 2025 Jul 4;44(4):748-758. doi: 10.5937/jomb0-52085.
To investigate how serum sST2 and cfDNA can be used to inform evidence-based nursing practices for children with severe pneumonia and myocardial damage.
100 children with severe pneumonia complicated with myocardial damage were recruited as research subjects. After assessing serum sST2 and cfDNA concentrations, the individuals were categorised into a control cohort (receiving standard treatment, n=50) and an experimental cohort (receiving evidence-based treatment guided by serum sST2 and cfDNA markers, n=50). Collected were the general details of the two patient groups. Biochemical analysis of patient serum sST2 and cfDNA changes was performed before and after care. Echocardiography was used to measure the left ventricular ejection fraction (LVEF) and left ventricular internal diameter (LVIDd) both before and after treatment of the patient. Levels of procalcitonin and C-reactive protein were assessed using enzyme-linked immunosorbent assay (ELISA) before and after patient treatment, while the white blood cell count in blood samples was determined using an automated haematology analyser. The patients' pneumonia resolution and length of hospital stay were compared. Patient satisfaction with care plans was compared through rating questionnaires.
The general information of the two groups of patients showed no significant difference (P>0.05). Before receiving nursing care, there were no significant variations in serum sST2 and cfDNA levels among the two patient groups (P>0.05). Following the nursing period, the observation group exhibited decreased serum sST2 and cfDNA levels compared to the control group (P<0.05). Before nursing care, there were no significant variations in left ventricular ejection fraction and left ventricular internal diameter in diastole among the two cohorts of patients (P>0.05). Following nursing, the observation group exhibited a higher LVEF than the control group and a smaller LVIDd (P<0.05). Before receiving nursing care, there were no significant variations in procalcitonin, hs-CRP, and white blood cell count between the two patient groups (P>0.05). Following care, the observation group exhibited decreased levels of procalcitonin, hs-CRP, and white blood cell count compared to the control group (P<0.05). The pneumonia remission and hospitalisation duration in the observation group were significantly shorter than in the control group (P<0.05).
The importance of serum sST2 and cfDNA indicators in evidence-based nursing for children with severe pneumonia and myocardial damage is highlighted, showing significant improvement in treatment outcomes and patient satisfaction, confirming the crucial role of these biomarkers in enhancing nursing care plans.
探讨血清可溶性生长刺激表达基因2蛋白（sST2）和循环游离DNA（cfDNA）如何用于为重症肺炎合并心肌损伤患儿制定循证护理方案。
招募100例重症肺炎合并心肌损伤患儿作为研究对象。评估血清sST2和cfDNA浓度后，将个体分为对照组（接受标准治疗，n = 50）和试验组（接受基于血清sST2和cfDNA标志物指导的循证治疗，n = 50）。收集两组患者的一般资料。对患者护理前后的血清sST2和cfDNA变化进行生化分析。使用超声心动图测量患者治疗前后的左心室射血分数（LVEF）和左心室内径（LVIDd）。采用酶联免疫吸附测定（ELISA）法评估患者治疗前后的降钙素原和C反应蛋白水平，同时使用自动血液分析仪测定血样中的白细胞计数。比较患者肺炎的缓解情况和住院时间。通过评分问卷比较患者对护理方案的满意度。
两组患者的一般资料无显著差异（P>0.05）。在接受护理前，两组患者血清sST2和cfDNA水平无显著差异（P>0.05）。护理期结束后，试验组血清sST2和cfDNA水平低于对照组（P<0.05）。护理前，两组患者的左心室射血分数和舒张期左心室内径无显著差异（P>0.05）。护理后，试验组的LVEF高于对照组，LVIDd小于对照组（P<0.05）。护理前，两组患者的降钙素原、超敏C反应蛋白和白细胞计数无显著差异（P>0.05）。护理后，试验组的降钙素原、超敏C反应蛋白和白细胞计数水平低于对照组（P<0.05）。试验组肺炎缓解情况和住院时间显著短于对照组（P<0.05）。
强调了血清sST2和cfDNA指标在重症肺炎合并心肌损伤患儿循证护理中的重要性，显示出治疗效果和患者满意度有显著改善，证实了这些生物标志物在完善护理方案中的关键作用。
