Clinical significance of immune-related antigen CD58 in gliomas and analysis of its potential core related gene clusters.

BACKGROUND

The clinical significance of immune-related antigen in gliomas remains uncertain. The aim of this study was to examine the clinical importance and possible core related genes of CD58 in gliomas.

METHODS

Pan-cancer analysis was to observe the association between and different tumors, glioma RNA sequencing data and clinical sample analyses were used to observe the relationship between and glioma, shRNA interference models were to observe the impact of on glioma cell function, and four glioma datasets and two online analysis platforms were used to explore the core related genes affecting the correlation between and glioma.

RESULTS

High expression was associated with worse prognosis in various tumors and higher malignancy in glioma. Down regulation of CD58 expression was linked to decreased proliferation, increased apoptosis, and reduced metastasis in glioma cells. The pathways involved in -related effects were enriched for immune cell adhesion and immune factor activation, and the core genes were and . The signature of and its core-related genes showed superior predictive power for glioma prognosis.

CONCLUSION

High expression is correlated with more malignant glioma types, and also an independent risk factor for mortality in glioma. and its core-related genes may serve as novel biomarkers for diagnosing and treating glioma.