Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research, Hyderabad, Telangana, 500037, India.
Nanomedicine (Lond). 2024;19(13):1145-1166. doi: 10.2217/nnm-2024-0013. Epub 2024 May 3.
To investigate the pemetrexed encapsulated polymeric mixed micelles (PMMs) against breast cancer treatment. We meticulously optimized the formulation and conducted extensive characterizations, including photon correlation spectroscopy for micellization, advanced analytical techniques and cell line assessments. The PMM exhibited favorable characteristics, with a spherical morphology, hydrodynamic particle size of 19.58 ± 0.89 nm, polydispersity index of 0.245 ± 0.1, and a surface charge of -9.70 ± 0.61 mV. Encapsulation efficiency and drug payload reached 96.16 ± 0.37% and 4.5 ± 0.32%, respectively. Cytotoxicity analysis indicated superior efficacy of the PMM over the drug solution. The PMM formulation exhibited controlled release of the drug, and demonstrated enhanced cytotoxicity against breast cancer cells, highlighting its therapeutic promise.
研究多西紫杉醇包封的聚合物混合胶束（PMMs）对乳腺癌的治疗作用。我们精心优化了配方，并进行了广泛的表征，包括胶束化的光相关光谱法、先进的分析技术和细胞系评估。PMM 表现出良好的特性，具有球形形态、水动力粒径为 19.58±0.89nm、多分散指数为 0.245±0.1 和表面电荷为-9.70±0.61mV。包封效率和药物载量分别达到 96.16±0.37%和 4.5±0.32%。细胞毒性分析表明，PMM 比药物溶液具有更好的疗效。PMM 制剂表现出药物的控制释放，并对乳腺癌细胞显示出增强的细胞毒性，突出了其治疗潜力。
