Assistant Professor, Department of Neurology, Government Medical College, Thiruvananthapuram, Kerala, India, Corresponding Author.
Associate Professor, Department of Neurology, Government Medical College, Thiruvananthapuram, Kerala, India.
J Assoc Physicians India. 2023 Sep;71(9):69-71. doi: 10.59556/japi.71.0317.
Guillain-Barre syndrome (GBS) is one of the most common neurological manifestations associated with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. Although data for a strong causal association is lacking, anecdotal reports, case series and systematic reviews linking the two have emerged in the literature. This prompted us to compare the clinical features, electrophysiology, and outcomes of GBS cases presenting during the pandemic with cases reported during a similar time period prior to the pandemic.
Prospective data of GBS cases diagnosed as per the National Institute of Neurological Disorders and Stroke (NINDS) criteria was collected for a 6-month period (July-December 2021) at three tertiary care teaching hospitals during the coronavirus pandemic and compared with retrospective records-based data of cases prior to the pandemic (January-July 2019).
A total of 40 cases were included in the cases, out of which 17 were in the prepandemic and 23 in the postpandemic period. A total of three cases temporally related to coronavirus disease 2019 (COVID-19) infection and four cases following COVID-19 vaccination were seen in the pandemic cohort. The clinical features, electrophysiological features, and outcomes were comparable during both periods. A slightly higher rate of in-hospital complications and single mortality was reported in the postpandemic period.
The number of GBS hospital admissions, clinical presentation, electrodiagnostic features, and short-term outcomes did not differ significantly between the prepandemic and postpandemic periods; a slightly higher incidence of in-hospital complications was observed during the pandemic period. How to cite this article: Panicker P, R D, V AG, et al. Comparison of Guillain-Barre Syndrome Cases during and Prior to the COVID-19 Pandemic: A Multicentric Study. J Assoc Physicians India 2023;71(9):69-71.
吉兰-巴雷综合征（GBS）是与严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）感染相关的最常见神经学表现之一。尽管缺乏强有力的因果关联数据，但文献中已经出现了将两者联系起来的传闻报告、病例系列和系统评价。这促使我们比较大流行期间出现的 GBS 病例的临床特征、电生理学和结局与大流行前类似时期报告的病例。
在冠状病毒大流行期间，我们在三家三级护理教学医院收集了按照国家神经病学疾病和中风研究所（NINDS）标准诊断的 GBS 病例的前瞻性数据，为期 6 个月（2021 年 7 月至 12 月），并与大流行前基于回顾性记录的病例（2019 年 1 月至 7 月）进行比较。
共纳入 40 例病例，其中 17 例为大流行前，23 例为大流行后。在大流行队列中，共发现 3 例与 2019 年冠状病毒病（COVID-19）感染有关，4 例与 COVID-19 接种后有关。在两个时期，临床特征、电生理特征和结局相似。大流行后住院并发症和单一死亡率略高。
大流行前后，GBS 住院人数、临床表现、电诊断特征和短期结局无显著差异；大流行期间观察到住院并发症发生率略高。
Panicker P, R D, V AG, et al. Comparison of Guillain-Barre Syndrome Cases during and Prior to the COVID-19 Pandemic: A Multicentric Study. J Assoc Physicians India 2023;71(9):69-71.
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