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脑动静脉畸形的治疗。

Treatment of Brain Arteriovenous Malformations.

机构信息

Department of Neurosurgery and Neurooncology, Military University Hospital, First Faculty of Medicine, Charles University, Prague, Czech Republic.

Department of Neurosurgery, Motol University Hospital, Second Faculty of Medicine, Charles University, Prague, Czech Republic.

出版信息

Adv Tech Stand Neurosurg. 2024;49:139-179. doi: 10.1007/978-3-031-42398-7_8.

Abstract

Brain arteriovenous malformations (AVMs) are a rare entity of vascular anomalies, characteristic of anatomical shunting where arterial blood directly flows into the venous circulation. The main aim of the active treatment policy of brain AVMs is the prevention of haemorrhage. There are well-established treatment strategies that continually improve in their safety and efficacy, primarily due to the advances in imaging modalities, targeted and novel techniques, the development of alternative treatment approaches, and even better experience with the disease itself. There are interesting imaging novelties that may be prospectively applicable in the decision-making and planning of the most effective treatment approach for individual patients with intracranial AVM. Surgery is often considered the first-line treatment; however, each patient should be evaluated individually, and the risks of the active treatment policy should not overcome the benefits of the spontaneous natural history of the disease. All treatment modalities, i.e., surgery, radiosurgery, endovascular embolization, and observation, are justified but need to be meticulously selected for each individual patient in order to deliver the best treatment outcome. This chapter deals with historical and currently applied dogmas, followed by introductions of advances in each available treatment modality of AVM management.

摘要

脑动静脉畸形(AVM)是一种罕见的血管畸形,其特征为解剖性分流,动脉血直接流入静脉循环。脑 AVM 积极治疗策略的主要目的是预防出血。目前已有成熟的治疗策略,其安全性和疗效不断提高,主要归因于成像方式、靶向和新型技术的进步、替代治疗方法的发展,以及对该疾病本身的经验积累。有一些有趣的影像学新进展,可能有望在决策和规划颅内 AVM 患者最有效治疗方法方面得到应用。手术通常被认为是一线治疗方法;然而,每位患者都应进行个体化评估,且积极治疗策略的风险不应超过疾病自然史的益处。所有治疗方法,即手术、放射外科、血管内栓塞和观察,都有其合理性,但需要为每位患者精心选择,以达到最佳治疗效果。本章讨论了历史上和目前应用的教条,随后介绍了 AVM 管理的每种现有治疗方法的进展。

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