State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875, China; Beijing Key Laboratory of Brain Imaging and Connectomics, Beijing Normal University, Beijing 100875, China; IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing 100875, China.
Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science & Medical Engineering, Beihang University, Beijing 100083, China.
Cell Rep. 2024 May 28;43(5):114168. doi: 10.1016/j.celrep.2024.114168. Epub 2024 May 2.
The first 1,000 days of human life lay the foundation for brain development and later cognitive growth. However, the developmental rules of the functional connectome during this critical period remain unclear. Using high-resolution, longitudinal, task-free functional magnetic resonance imaging data from 930 scans of 665 infants aged 28 postmenstrual weeks to 3 years, we report the early maturational process of connectome segregation and integration. We show the dominant development of local connections alongside a few global connections, the shift of brain hubs from primary regions to high-order association cortices, the developmental divergence of network segregation and integration along the anterior-posterior axis, the prediction of neurocognitive outcomes, and their associations with gene expression signatures of microstructural development and neuronal metabolic pathways. These findings advance our understanding of the principles of connectome remodeling during early life and its neurobiological underpinnings and have implications for studying typical and atypical development.
人类生命的头 1000 天为大脑发育和以后的认知成长奠定了基础。然而，在这个关键时期，功能性连接组的发展规律尚不清楚。我们使用来自 665 名 28 孕周至 3 岁婴儿的 930 次高分辨率、纵向、无任务功能磁共振成像数据，报告了连接组分离和整合的早期成熟过程。我们显示了局部连接的主导发展，以及少量的全局连接，大脑枢纽从主要区域向高级联合皮质的转移，网络分离和整合沿着前后轴的发展分歧，神经认知结果的预测，以及它们与微观结构发育和神经元代谢途径的基因表达特征的关联。这些发现增进了我们对生命早期连接组重塑原则及其神经生物学基础的理解，并对研究正常和异常发育具有重要意义。
