Department of Biology, College of Science, Mustansiriyah University, Bagdad, Iraq.
Cytokine. 2024 Jul;179:156632. doi: 10.1016/j.cyto.2024.156632. Epub 2024 May 2.
The study was planned to evaluate the differences in certain proinflammatory cytokines(IL-6, TNF-α) with CRP and biochemical parameters (E2, D3, LDH, GGT, TSB, Ca, Ph, uric acid), between women with pre- and postmenopausal breast cancer and seemingly healthy women in Iraqi women as controls; at medical city in teaching Oncology hospital,70 breast cancer patients women their ages ranged (47.51 ± 1.18) and 20 healthy women with age (44.45 ± 2.66) begun from September (2020) to February (2021). The aims of this study to investigate the evaluation of chemotherapy effects especially doxorubicin and cyclophosphamide only use in this study in pre and postmenopausal breast cancer women on proinflammatory cytokines(IL-6, TNF-α) with CRP and on biochemical parameters(E2, D3, LDH, GGT, TSB, Ca, Ph, uric acid) in pre and postmenapausal breast cancer women. The patients were divided into five groups and each group contains 14 patients women with breast cancer during pre and postmenopausal periods. The control groups were divided into 10 pre and 10 postmenopausal women(Fig. 1). The results of proinflammatory cytokines of and biochemical parameters in premenopausal groups were as the levels of IL-6 (pg/ml),TNF-α(pg/ml) and CRP (ng/ml) showed significant increase differences (P < 0.01)among breast cancer treated (BCT) groups in comparison with control groups,While the Liver enzymes GGT,LDH and TSB showed highly significant increase (P < 0.01) in BCT groups, Estrogen levels (pg/ml) and D3(ng/ml) increased significantly (P < 0.01)among BCT groups. Blood serum calcium and phosphorus with uric acid levels (mg/dl) showed significant difference (P < 0.01); While the result in postmenopausal of IL-6(pg/ml), TNF-α (pg/ml) and CRP (ng/ml) showed highly significant differences (P < 0.01)among BCT groups.While GGT(IU/L), LDH(IU/L) and TSB (mg/dl) enzymes were increased significantly (p < 0.01), Estrogen (pg/ml) and D3(ng/ml) levels showed significant increase (P < 0.01) among BCT groups.Blood calcium and phosphorus showed significant increase (P < 0.01) while uric acid was non-significant increase (P > 0.05).
这项研究旨在评估炎症细胞因子（IL-6、TNF-α）与 CRP 以及生化参数（E2、D3、LDH、GGT、TSB、Ca、Ph、尿酸）在伊拉克女性中，绝经前和绝经后乳腺癌患者与对照组（似乎健康的女性）之间的差异。在医学城教学肿瘤医院，共招募了 70 名年龄在（47.51 ± 1.18）岁的乳腺癌患者和 20 名年龄在（44.45 ± 2.66）岁的健康女性作为对照组。本研究的目的是评估化疗效果，特别是阿霉素和环磷酰胺在绝经前和绝经后乳腺癌患者中的应用，研究炎症细胞因子（IL-6、TNF-α）与 CRP 以及生化参数（E2、D3、LDH、GGT、TSB、Ca、Ph、尿酸）的变化。患者被分为五组，每组有 14 名绝经前和绝经后乳腺癌患者。对照组分为 10 名绝经前和 10 名绝经后女性（图 1）。结果显示，在绝经前组中，炎症细胞因子和生化参数的水平，如 IL-6（pg/ml）、TNF-α（pg/ml）和 CRP（ng/ml），在接受治疗的乳腺癌患者（BCT）组与对照组之间有显著差异（P < 0.01），而 GGT、LDH 和 TSB 等肝酶则显著升高（P < 0.01）。BCT 组中雌激素水平（pg/ml）和 D3（ng/ml）显著升高（P < 0.01）。血清钙、磷和尿酸水平（mg/dl）有显著差异（P < 0.01）。在绝经后组中，IL-6（pg/ml）、TNF-α（pg/ml）和 CRP（ng/ml）在 BCT 组中差异有统计学意义（P < 0.01）。GGT（IU/L）、LDH（IU/L）和 TSB（mg/dl）酶显著升高（P < 0.01），BCT 组中雌激素（pg/ml）和 D3（ng/ml）水平显著升高（P < 0.01）。血清钙、磷水平显著升高（P < 0.01），尿酸水平无显著升高（P > 0.05）。
