Department of Lab Medicine & Pathology, University of Washington, Seattle, WA 98195, USA; Institute for Stem Cell & Regenerative Medicine, University of Washington, Seattle, WA 98109, USA; Center for Cardiovascular Biology, University of Washington, Seattle, WA 98109, USA.
Department of Lab Medicine & Pathology, University of Washington, Seattle, WA 98195, USA; Department of Bioengineering, University of Washington, Seattle, WA 98105, USA; Institute for Stem Cell & Regenerative Medicine, University of Washington, Seattle, WA 98109, USA; Center for Cardiovascular Biology, University of Washington, Seattle, WA 98109, USA.
Cell Stem Cell. 2024 May 2;31(5):589-590. doi: 10.1016/j.stem.2024.04.009.
Poorly regenerative organs deposit scar tissue to mend damage. Aggarwal et al. establish that transient Sox9 activity is necessary for early proximal tubule epithelial regeneration, while Trogisch et al. and Aggarwal et al. show that persistent Sox9 activity in epithelial and endothelial cells activates fibroblasts creating fibrotic microdomains in multiple organs.
再生能力差的器官会沉积疤痕组织来修复损伤。Aggarwal 等人证实，Sox9 活性的短暂激活对于早期近端肾小管上皮细胞的再生是必要的，而 Trogisch 等人和 Aggarwal 等人则表明，上皮细胞和内皮细胞中 Sox9 活性的持续激活会激活成纤维细胞，从而在多个器官中形成纤维性微区。
