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在纤维化肾脏发育过程中，肾细胞通过WNT信号转导的相互作用。

Cross-talk of renal cells through WNT signal transduction in the development of fibrotic kidneys.

作者信息

Chen Yuhong, Xue Chao

机构信息

Department of Nephrology, The Second Affiliated Hospital of Guangxi Medical University, Nanning, China.

出版信息

Front Cell Dev Biol. 2025 Feb 12;12:1517181. doi: 10.3389/fcell.2024.1517181. eCollection 2024.

DOI:10.3389/fcell.2024.1517181
PMID:40012992
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11860889/
Abstract

Chronic kidney disease (CKD) is a progressive condition that can lead to chronic renal failure (CRF), affecting 8%-16% of adults globally and imposing a significant burden on healthcare systems. Renal fibrosis is a key pathological hallmark of CKD progression and is linked to poor prognosis. Multiple signaling pathways, including WNT/β-catenin.Aberrant activation of WNT/β-catenin is implicated in renal fibrosis. The roles of renal macrophages and fibroblasts are pivotal in fibrosis progression and prognosis.

摘要

慢性肾脏病（CKD）是一种会导致慢性肾衰竭（CRF）的进行性疾病，全球8%-16%的成年人受其影响，给医疗系统带来了沉重负担。肾纤维化是CKD进展的关键病理标志，与不良预后相关。多种信号通路，包括WNT/β-连环蛋白。WNT/β-连环蛋白的异常激活与肾纤维化有关。肾巨噬细胞和成纤维细胞在纤维化进展和预后中起关键作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c03/11860889/ed7a4e55e68f/fcell-12-1517181-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c03/11860889/1197c3ef3670/fcell-12-1517181-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c03/11860889/ed7a4e55e68f/fcell-12-1517181-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c03/11860889/1197c3ef3670/fcell-12-1517181-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c03/11860889/ed7a4e55e68f/fcell-12-1517181-g002.jpg

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2
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Adv Sci (Weinh). 2024 Oct;11(38):e2309752. doi: 10.1002/advs.202309752. Epub 2024 Aug 9.
3
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Front Biosci (Landmark Ed). 2024 May 16;29(5):192. doi: 10.31083/j.fbl2905192.
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