癌症干性的特征。

Hallmarks of cancer stemness.

机构信息

School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.

School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China; State Key Laboratory of Liver Research, The University of Hong Kong, Hong Kong SAR, China; Laboratory of Synthetic Chemistry and Chemical Biology, Hong Kong Science and Technology Park, Hong Kong SAR, China; Centre for Translational and Stem Cell Biology, Hong Kong Science and Technology Park, Hong Kong SAR, China.

出版信息

Cell Stem Cell. 2024 May 2;31(5):617-639. doi: 10.1016/j.stem.2024.04.004.

DOI:10.1016/j.stem.2024.04.004

PMID:38701757

Abstract

Cancer stemness is recognized as a key component of tumor development. Previously coined "cancer stem cells" (CSCs) and believed to be a rare population with rigid hierarchical organization, there is good evidence to suggest that these cells exhibit a plastic cellular state influenced by dynamic CSC-niche interplay. This revelation underscores the need to reevaluate the hallmarks of cancer stemness. Herein, we summarize the techniques used to identify and characterize the state of these cells and discuss their defining and emerging hallmarks, along with their enabling and associated features. We also highlight potential future directions in this field of research.

摘要

癌症干细胞特性被认为是肿瘤发展的关键组成部分。此前被称为“癌症干细胞”（CSC），并被认为是具有严格层次组织的稀有群体，有充分的证据表明这些细胞表现出一种可塑性的细胞状态，受到动态 CSC-生态位相互作用的影响。这一发现强调了需要重新评估癌症干细胞特性的标志性特征。在此，我们总结了用于识别和描述这些细胞状态的技术，并讨论了它们的定义和新兴标志性特征，以及它们的使能和相关特征。我们还强调了该研究领域的潜在未来方向。