Division of Medical Oncology, Department of Internal Medicine, The Ohio State University College of Medicine, Columbus, OH, 43210, USA; The Ohio State University Comprehensive Cancer Center, Columbus, OH, 43210, USA.
Cancer Lett. 2024 Jun 28;592:216931. doi: 10.1016/j.canlet.2024.216931. Epub 2024 May 1.
The intricate role of inducible nitric oxide synthase (iNOS) in cancer pathophysiology has garnered significant attention, highlighting the complex interplay between tumorigenesis, immune response, and cellular metabolism. As an enzyme responsible for producing nitric oxide (NO) in response to inflammatory stimuli. iNOS is implicated in various aspects of cancer development, including DNA damage, angiogenesis, and evasion of apoptosis. This review synthesizes the current findings from both preclinical and clinical studies on iNOS across different cancer types, reflecting the variability depending on cellular context and tumor microenvironment. We explore the molecular mechanisms by which iNOS modulates cancer cell growth, survival, and metastasis, emphasizing its impact on immune surveillance and response to treatment. Additionally, the potential of targeting iNOS as a therapeutic strategy in cancer treatment is examined. By integrating insights from recent advances, this review aims to elucidate the significant role of iNOS in cancer and pave the way for novel diagnostic and therapeutic approaches.
诱导型一氧化氮合酶 (iNOS) 在癌症病理生理学中的复杂作用引起了广泛关注，突出了肿瘤发生、免疫反应和细胞代谢之间的复杂相互作用。作为一种响应炎症刺激产生一氧化氮 (NO) 的酶，iNOS 参与了癌症发展的各个方面，包括 DNA 损伤、血管生成和细胞凋亡的逃逸。本综述综合了不同癌症类型中 iNOS 的临床前和临床研究的最新发现，反映了其取决于细胞背景和肿瘤微环境的可变性。我们探讨了 iNOS 调节癌细胞生长、存活和转移的分子机制，强调了其对免疫监测和治疗反应的影响。此外，还研究了将 iNOS 作为癌症治疗的治疗策略的潜力。通过整合最近进展的见解，本综述旨在阐明 iNOS 在癌症中的重要作用，并为新的诊断和治疗方法铺平道路。
