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Impact of Teriparatide on Complications and Patient-Reported Outcomes of Patients Undergoing Long Spinal Fusion According to Bone Density.根据骨密度评估特立帕肽对接受长节段脊柱融合术患者并发症及患者报告结局的影响
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The Possible Role of Electrical Stimulation in Osteoporosis: A Narrative Review.电刺激在骨质疏松症中的可能作用:叙述性综述。
Medicina (Kaunas). 2023 Jan 8;59(1):121. doi: 10.3390/medicina59010121.
3
ACR Appropriateness Criteria® Osteoporosis and Bone Mineral Density: 2022 Update.ACR 适宜性标准®骨质疏松症和骨密度:2022 年更新。
J Am Coll Radiol. 2022 Nov;19(11S):S417-S432. doi: 10.1016/j.jacr.2022.09.007.
4
Twelve-Month Results from a Prospective Clinical Study Evaluating the Efficacy and Safety of Cellular Bone Allograft in Subjects Undergoing Lumbar Spinal Fusion.一项评估细胞骨移植在接受腰椎融合术患者中的疗效和安全性的前瞻性临床研究的12个月结果。
Neurol Int. 2022 Oct 26;14(4):875-883. doi: 10.3390/neurolint14040070.
5
Management of Osteoporosis and Spinal Fractures: Contemporary Guidelines and Evolving Paradigms.骨质疏松症与脊柱骨折的管理:当代指南与不断变化的理念。
Clin Med Res. 2022 Jun;20(2):95-106. doi: 10.3121/cmr.2021.1612. Epub 2022 Apr 27.
6
The clinician's guide to prevention and treatment of osteoporosis.临床医生骨质疏松症防治指南。
Osteoporos Int. 2022 Oct;33(10):2049-2102. doi: 10.1007/s00198-021-05900-y. Epub 2022 Apr 28.
7
Radiological Evaluation of Combined Anteroposterior Fusion with Vertebral Body Replacement Using a Minimally Invasive Lateral Approach for Osteoporotic Vertebral Fractures: Verification of Optimal Surgical Procedure.使用微创外侧入路行椎体置换联合前后路融合术治疗骨质疏松性椎体骨折的影像学评估:最佳手术方法的验证
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Best Practice Guidelines for Assessment and Management of Osteoporosis in Adult Patients Undergoing Elective Spinal Reconstruction.成人择期脊柱重建患者骨质疏松评估和管理的最佳实践指南。
Spine (Phila Pa 1976). 2022 Jan 15;47(2):128-135. doi: 10.1097/BRS.0000000000004268.
9
The impact of osteoporosis on adult deformity surgery outcomes in Medicare patients.骨质疏松症对医疗保险患者成人畸形手术结局的影响。
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10
Congress of Neurological Surgeons Systematic Review and Evidence-Based Guidelines for Perioperative Spine: Preoperative Osteoporosis Assessment.神经外科医师协会系统评价与循证指南:脊柱围手术期-术前骨质疏松评估。
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评估老年脊柱中的骨质疏松症和骨质量:老年人群外科管理的现代考虑因素。

Evaluating osteoporosis and bone quality in the aging spine: modern considerations for surgical management in the geriatric population.

机构信息

Department of Neurosurgery, Mayo Clinic Arizona, Phoenix, AZ, USA.

Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.

出版信息

Geroscience. 2024 Oct;46(5):5287-5301. doi: 10.1007/s11357-024-01171-7. Epub 2024 May 4.

DOI:10.1007/s11357-024-01171-7
PMID:38703277
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11336023/
Abstract

Surgical management paradigms of spinal pathologies in the aging population carry inherent substantial risks, with surgical complications being more prevalent among patients with osteoporosis compared to those with normal bone mineral density. In this narrative review, we aim to highlight important clinical understanding and considerations in perioperative evaluation and management of patients elected to undergo spinal surgery. Osteoporosis is a well-defined risk factor for mechanical complications following spinal surgery, and as such, perioperative optimization of bone health in the setting of surgery for geriatric patients remains a critical research area alongside intraoperative surgical augmentation techniques. Surgical techniques to circumvent challenges with instrumentation of poor bone mineral density have included augmentation of pedicle screw fixation, including segmental bicortical screw fixation techniques, cement augmentation with fenestrated screws, or use of expandable pedicle screws to improve bone-implant interface. Judicious selection of treatment modalities and subsequent perioperative optimization is paramount to minimize surgical complications. Contemporary guidelines and evolving paradigms in perioperative evaluation, optimization, and management of the aging spine include the advent of quantitatively evaluating computed tomography (CT) via assessment of the magnitude of Hounsfield units. Prescribing pharmacotherapeutic agents and monitoring bone health requires a multidisciplinary team approach, including endocrinologists and geriatricians to coordinate high-quality care for advanced-age patients who require surgical management of their spinal disorders.

摘要

在老年人群中,脊柱病变的手术治疗模式存在固有风险,骨质疏松症患者的手术并发症比正常骨密度患者更为常见。在这篇叙述性综述中,我们旨在强调在选择接受脊柱手术的患者的围手术期评估和管理中需要重要的临床理解和考虑。骨质疏松症是脊柱手术后机械性并发症的明确危险因素,因此,老年患者手术时优化骨骼健康仍然是一个关键的研究领域,同时还需要研究术中手术增强技术。为了规避骨密度不佳的器械应用挑战而采用的手术技术包括增加椎弓根螺钉固定,包括节段性皮质骨螺钉固定技术、带孔螺钉的骨水泥增强,或使用可扩张椎弓根螺钉来改善骨-植入物界面。明智地选择治疗方式并进行后续的围手术期优化对于最大限度地减少手术并发症至关重要。老年脊柱的围手术期评估、优化和管理的当代指南和不断发展的模式包括通过评估亨氏单位的幅度来定量评估计算机断层扫描(CT)。为了为需要手术治疗脊柱疾病的高龄患者提供高质量的护理,需要内分泌学家和老年病学家等多学科团队来开处药物治疗并监测骨骼健康。