Malhi Amarveer, Padda Inderbir, Mahtani Arun, Fabian Daniel, Karroum Paul, Mathews Arpita M, Ralhan Tushar, Sethi Yashendra, Emran Talha B
Department of Medicine, CMU School of Medicine, Netherlands, Antilles.
Department of Internal Medicine, Richmond University Medical Center/Mount Sinai, Staten Island, New York, USA.
Int J Surg. 2024 Oct 1;110(10):6345-6354. doi: 10.1097/JS9.0000000000001537.
Cardiovascular diseases stemming from various factors significantly impact the quality of life and are prevalent with high mortality rates in both developed and developing countries. In cases where pharmacotherapy proves insufficient and end-stage disease ensues, a heart transplant/surgical repair becomes the only feasible treatment option. However, challenges such as a limited supply of heart donors, complications associated with rejection, and issues related to medication compliance introduce an additional burden to the healthcare system and adversely affect patient outcomes. The emergence of bioprinting has facilitated advancements in creating structures, including ventricles, valves, and blood vessels. Notably, the development of myocardial/cardiac patches through bioprinting has offered a promising avenue for revascularizing, strengthening, and regenerating various cardiovascular structures. Employment loss in developing countries as a circumstance of disability or death can severely impact a family's well-being and means for sustainable living. Innovations by means of life sustaining treatment options can provide hope for the impoverished and help reduce disability burden on the economy of low- and middle-income countries (LMICs). Such developments can have a significant impact that can last for generations, especially in these countries. In this review, the authors delve into various types of bioprinting techniques, exploring their possibilities, challenges, and potential future applications in treating various end-stage cardiovascular conditions in LMICs.
由多种因素引起的心血管疾病严重影响生活质量，在发达国家和发展中国家都很普遍，死亡率很高。在药物治疗被证明不足并出现终末期疾病的情况下，心脏移植/手术修复成为唯一可行的治疗选择。然而，诸如心脏供体供应有限、与排斥相关的并发症以及与药物依从性相关的问题等挑战给医疗系统带来了额外负担，并对患者的治疗结果产生不利影响。生物打印技术的出现推动了包括心室、瓣膜和血管在内的结构的创建方面的进展。值得注意的是，通过生物打印开发心肌/心脏补片为各种心血管结构的血管再生、强化和再生提供了一条有前景的途径。在发展中国家，因残疾或死亡导致的就业损失会严重影响家庭的福祉和可持续生活的手段。通过维持生命的治疗选择进行创新可以为贫困人口带来希望，并有助于减轻低收入和中等收入国家（LMICs）经济上的残疾负担。这样的发展可能会产生持续几代人的重大影响，尤其是在这些国家。在这篇综述中，作者深入探讨了各种生物打印技术，探索它们在治疗LMICs各种终末期心血管疾病方面的可能性、挑战和潜在的未来应用。
