Moinuddin Arsalan, Ali Syed Yusuf, Goel Ashish, Sethi Yashendra, Patel Neil, Kaka Nirja, Satapathy Prakasini, Sah Ranjit, Barboza Joshuan J, Suhail Mohammed K
School of Sport and Exercise, University of Gloucestershire, Gloucester, United Kingdom.
Department of Biomedical Engineering, Johns Hopkins University, Balimore, MD, United States.
Front Cardiovasc Med. 2023 Sep 14;10:1233991. doi: 10.3389/fcvm.2023.1233991. eCollection 2023.
Ventricular arrhythmias, particularly ventricular tachycardia, are ubiquitously linked to 300,000 deaths annually. However, the current interventional procedure-the cardiac ablation-predict only short-term responses to treatment as the heart constantly remodels itself post-arrhythmia. To assist in the design of computational methods which focuses on long-term arrhythmia prediction, this review postulates three interdependent prospectives. The main objective is to propose computational methods for predicting long-term heart response to interventions in ventricular tachycardia Following a general discussion on the importance of devising simulations predicting long-term heart response to interventions, each of the following is discussed: (i) application of "metabolic sink theory" to elucidate the "re-entry" mechanism of ventricular tachycardia; (ii) application of "growth laws" to explain "mechanical load" translation in ventricular tachycardia; (iii) derivation of partial differential equations (PDE) to establish a pipeline to predict long-term clinical outcomes in ventricular tachycardia.
室性心律失常，尤其是室性心动过速，每年导致30万人死亡。然而，目前的介入治疗方法——心脏消融术——只能预测治疗的短期反应，因为心律失常后心脏会不断重塑自身。为了协助设计专注于长期心律失常预测的计算方法，本综述提出了三个相互依存的前瞻性观点。主要目标是提出用于预测室性心动过速干预后心脏长期反应的计算方法。在对设计预测心脏对干预的长期反应的模拟的重要性进行一般性讨论之后，接着讨论以下内容：(i) 应用“代谢汇理论”来阐明室性心动过速的“折返”机制；(ii) 应用“生长定律”来解释室性心动过速中的“机械负荷”转化；(iii) 推导偏微分方程 (PDE) 以建立预测室性心动过速长期临床结果的流程。
