Rodary C, Elman A, Durand M, Cohen-Solal J, Maillard J N
Ann Anesthesiol Fr. 1979;20(2):118-20.
Eighty-four patients submitted to cholecystectomy were randomly assigned in a double-blind study either to an intravenous dose of 10 mg of metopimazine, three times D-1, for two days or to an identically administered placebo. A definite superiority of metopimazine as an anti-emetic drug was demonstrated. General acceptance was excellent, but arterial pressure might be looked over closely when metopimazine was administered intravenously immediately after a general anesthesia.
在一项双盲研究中，84例行胆囊切除术的患者被随机分为两组，一组静脉注射10毫克甲哌氯丙嗪，每日3次，共2天；另一组给予同样给药方式的安慰剂。结果表明，甲哌氯丙嗪作为一种止吐药物具有明显优势。总体接受度良好，但在全身麻醉后立即静脉注射甲哌氯丙嗪时，可能需要密切监测动脉血压。
