甲状腺受体 β：开发新型抗雄激素性脱发药物的有前途靶点。
Thyroid receptor β: A promising target for developing novel anti-androgenetic alopecia drugs.
机构信息
School of Pharmacy, Hangzhou Normal University, Hangzhou, 311121, P.R. China; Key Laboratory of Elemene Class Anti-tumor Chinese Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou 311121, PR China.
School of Pharmacy, Hangzhou Normal University, Hangzhou, 311121, P.R. China; Key Laboratory of Elemene Class Anti-tumor Chinese Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou 311121, PR China.
出版信息
Drug Discov Today. 2024 Jun;29(6):104013. doi: 10.1016/j.drudis.2024.104013. Epub 2024 May 3.
Androgenetic alopecia (AGA) significantly impacts the self-confidence and mental well-being of people. Recent research has revealed that thyroid receptor β (TRβ) agonists can activate hair follicles and effectively stimulate hair growth. This review aims to comprehensively elucidate the specific mechanism of action of TRβ in treating AGA from various perspectives, highlighting its potential as a drug target for combating AGA. Moreover, this review provides a thorough summary of the research advances in TRβ agonist candidates with anti-AGA efficacy and outlines the structure-activity relationships (SARs) of TRβ agonists. We hope that this review will provide practical information for the development of effective anti-alopecia drugs.
雄激素性脱发（AGA）显著影响人们的自信心和心理健康。最近的研究表明，甲状腺受体β（TRβ）激动剂可以激活毛囊，有效刺激头发生长。本综述旨在从多个角度全面阐明 TRβ 治疗 AGA 的具体作用机制，强调其作为治疗 AGA 药物靶点的潜力。此外，本综述还全面总结了具有抗 AGA 疗效的 TRβ 激动剂候选物的研究进展，并概述了 TRβ 激动剂的构效关系（SARs）。我们希望本综述能为开发有效的抗脱发药物提供实用信息。
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