解决早产难题。
Solving the Puzzle of Preterm Birth.
机构信息
Department of Pediatrics, Division of Neonatal and Developmental Medicine, Stanford University School of Medicine, Biomedical Innovations Building (BMI), 240 Pasteur Drive, Room 2652, Stanford, CA 94305, USA.
Department of Obstetrics and Gynecology, Division of Reproductive, Stem Cell and Perinatal Biology, Stanford University of School of Medicine, Biomedical Innovations Building (BMI), 240 Pasteur Drive, Module 2700, Stanford, CA 94305, USA.
出版信息
Clin Perinatol. 2024 Jun;51(2):291-300. doi: 10.1016/j.clp.2024.02.001. Epub 2024 Mar 8.
Solving the puzzle of preterm birth has been challenging and will require novel integrative solutions as preterm birth likely arises from many etiologies. It has been demonstrated that many sociodemographic and psychological determinants of preterm birth relate to its complex biology. It is this understanding that has enabled the development of a novel preventative strategy, which integrates the omics profile (genome, epigenome, transcriptome, proteome, metabolome, microbiome) with sociodemographic, environmental, and psychological determinants of individual pregnant people to solve the puzzle of preterm birth.
解决早产问题一直具有挑战性，并且可能需要新颖的综合解决方案，因为早产可能源于多种病因。已经证明，早产的许多社会人口学和心理决定因素与它的复杂生物学有关。正是这种理解使一种新的预防策略得以发展，该策略将组学特征（基因组、表观基因组、转录组、蛋白质组、代谢组和微生物组）与个体孕妇的社会人口学、环境和心理决定因素相结合，以解决早产问题。
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