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单中心观察性研究:局部麻醉下胸腔镜用于治疗胸部感染的安全性和有效性。

Single-centre observational study of the safety and efficacy of thoracoscopy under local anaesthesia for the management of thoracic infections.

机构信息

Division of Respiratory Medicine, Center for Respiratory Diseases, National Hospital Organization Kyoto Medical Center, 1-1, Fukakusa-Mukaihata, Fushimi, Kyoto, Kyoto, Japan.

HiLung Inc., Kyoto, Japan.

出版信息

BMC Res Notes. 2024 May 6;17(1):127. doi: 10.1186/s13104-024-06794-9.

Abstract

OBJECTIVES

Thoracoscopy under local anaesthesia is widely performed to diagnose malignancies and infectious diseases. However, few reports have described the use of this procedure for diagnosing and treating intrathoracic infections. This study aimed to evaluate the safety and efficacy of thoracoscopy under local anaesthesia for the management of intrathoracic infections.

RESULTS

Data from patients who underwent thoracoscopy procedures performed by chest physicians under local anaesthesia at our hospital between January 2018 and December 2023 were retrospectively reviewed. We analysed their demographic factors, reasons for the examinations, diseases targeted, examination lengths, anaesthetic methods used, diagnostic and treatment success rates, as well as any adverse events. Thirty patients were included. Of these, 12 (40%) had thoracoscopies to diagnose infections, and 18 (60%) had them to treat pyothorax. In terms of diagnosing pleurisy, the causative microorganism of origin was identified via thoracoscopy in only three of 12 (25.0%) patients. For diagnosing pyothorax, the causative microorganism was identified in 7 of 18 (38.9%) patients. Methicillin-resistant Staphylococcus aureus was the most common causative microorganism identified. The treatment success rates were very high, ranging between 94.4 and 100%, whereas the identification rate of the causative microorganisms behind infections was low, ranging between 25.0 and 38.9%. The most frequent adverse events included perioperative hypoxaemia and pain. There were two (6.7%) serious adverse events of grade ≥ 3, but none resulted in death.

CONCLUSIONS

The efficacy of managing intrathoracic infections through thoracoscopy under local anaesthesia is commendable. Nonetheless, the diagnostic accuracy of the procedure, regarding the precise identification of the causative microorganisms responsible for intrathoracic infections, persists at a notably low level, presenting a substantial clinical hurdle.

摘要

目的

局部麻醉下胸腔镜检查广泛用于诊断恶性肿瘤和传染病。然而,很少有报道描述该程序用于诊断和治疗胸腔内感染。本研究旨在评估局部麻醉下胸腔镜检查在胸腔内感染治疗中的安全性和有效性。

结果

回顾性分析了 2018 年 1 月至 2023 年 12 月期间我院胸部医生在局部麻醉下进行胸腔镜检查的患者数据。分析了他们的人口统计学因素、检查原因、目标疾病、检查长度、使用的麻醉方法、诊断和治疗成功率以及任何不良事件。共纳入 30 例患者。其中 12 例(40%)因感染行胸腔镜检查,18 例(60%)因脓胸行胸腔镜检查。在诊断胸膜炎方面,12 例患者中仅 3 例(25.0%)通过胸腔镜检查确定了致病微生物来源。在诊断脓胸方面,18 例患者中 7 例(38.9%)确定了致病微生物。耐甲氧西林金黄色葡萄球菌是最常见的致病微生物。治疗成功率非常高,在 94.4%至 100%之间,而感染的致病微生物的鉴定率较低,在 25.0%至 38.9%之间。最常见的不良事件包括围手术期低氧血症和疼痛。有 2 例(6.7%)严重不良事件为≥3 级,但均未导致死亡。

结论

局部麻醉下胸腔镜检查治疗胸腔内感染的疗效值得肯定。然而,该操作在准确识别导致胸腔内感染的致病微生物方面的诊断准确性仍处于较低水平,这是一个重大的临床难题。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e320/11071223/c1186bcd11f2/13104_2024_6794_Fig1_HTML.jpg

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