鱼类和贝类食用、认知健康与美国 60 岁及以上成年人阿尔茨海默病死亡率的关系。

Fish and Shellfish Consumption, Cognitive Health and Mortality from Alzheimer's Disease among US Adults Aged 60 and Older.

机构信息

Hongbing Sun, PhD, Nutrition and Health Study, Department of Earth and Chemistry, Rider University, 2083 Lawrenceville Road, Lawrenceville, New Jersey 08648, US. Email:

出版信息

J Prev Alzheimers Dis. 2024;11(3):632-638. doi: 10.14283/jpad.2024.57.

DOI:10.14283/jpad.2024.57

PMID:38706279

Abstract

BACKGROUND

Relationships of fish-shellfish consumption, cognitive health and mortality from Alzheimer's disease (AD) among US adults aged 60 years and older have not been adequately studied.

OBJECTIVES

To determine the relationship of fish-shellfish consumption, cognitive health and mortality from AD in US adults aged 60 years and older.

DESIGN, SETTING AND PARTICIPANTS: The data of this cross-sectional study of US adults aged 60 years and older were from the National Nutrition and Health Examination Survey (NHANES) datasets. Frequency of fish-shellfish consumption, its association with subjective cognitive decline (SCD) and AD mortality of these participants between 1999 and 2018 and cognitive assessment scores between 2011 and 2014 were analyzed.

MEASUREMENTS AND RESULTS

US adults aged 60 years and older consumed fish-shellfish 1.2 times/week and had a blood Hg of 1.63 ug/L on average between 1999 and 2018. Participants aged 60 years and older in the highest quartile of fish-shellfish consumption (~3 times/week) had significantly higher cognitive assessment scores than those in the lowest quartile (rare or no fish-shellfish consumption). Adults in the highest quartile of fish-shellfish consumption had a 30% lower risk (odds ratio 0.7, 95%CI 0.57-0.87) of SCD, and 44% lower risk (hazard ratio 0.56, 95%CI 0.35-0.9) of AD mortality than those in the lowest quartile.

CONCLUSION

Increased fish-shellfish consumption was associated with improved scores of cognitive assessment and reduced risks of SCD and AD mortality.

摘要

背景

在美国 60 岁及以上的成年人中，鱼类贝类的消费、认知健康与阿尔茨海默病（AD）死亡率之间的关系尚未得到充分研究。

目的

确定美国 60 岁及以上成年人中鱼类贝类消费、认知健康与 AD 死亡率之间的关系。

设计、地点和参与者：本横断面研究的数据来自美国 60 岁及以上成年人的国家营养与健康调查（NHANES）数据集。分析了这些参与者在 1999 年至 2018 年期间鱼类贝类消费的频率、与主观认知下降（SCD）和 AD 死亡率的关联，以及在 2011 年至 2014 年期间的认知评估得分。

测量和结果

美国 60 岁及以上成年人每周食用鱼类贝类 1.2 次，1999 年至 2018 年期间的平均血液汞含量为 1.63ug/L。在鱼类贝类消费最高四分位数（~3 次/周）的参与者中，认知评估得分明显高于最低四分位数（很少或从不食用鱼类贝类）。鱼类贝类消费最高四分位数的成年人患 SCD 的风险降低了 30%（优势比 0.7，95%CI 0.57-0.87），AD 死亡率的风险降低了 44%（风险比 0.56，95%CI 0.35-0.9），与最低四分位数相比。