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端粒维持的三种分子亚型的相互作用定义了胃癌的临床特征和肿瘤微环境。

Cross-talk of Three Molecular Subtypes of Telomere Maintenance Defines Clinical Characteristics and Tumor Microenvironment in Gastric Cancer.

作者信息

Yan Mengpei, Zhang Zhijun, Wang Luyao, Huang Hongxin, Wang Jihuan, Zhu Chengjun, Li Zheng, Xu Zekuan

机构信息

Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, Jiangsu Province, China.

Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, Jiangsu Province, China.

出版信息

J Cancer. 2024 Apr 15;15(10):3227-3241. doi: 10.7150/jca.92207. eCollection 2024.

DOI:10.7150/jca.92207
PMID:38706908
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11064253/
Abstract

Telomere maintenance takes part in the regulation of gastric cancer (GC) pathogenesis and is essential for patients' clinical features. Though the correlation between a single telomere maintenance-related gene and GC has previously been published, comprehensive exploration and systematic analysis remain to be studied. Our study is aimed at determining telomere maintenance-related molecular subtypes and examining their role in GC. By analyzing the transcriptome data, we identified three telomere maintenance-associated clusters (TMCs) with heterogeneity in clinical features and tumor microenvironment (TME). Then, we screened five prognostic telomere maintenance-related genes and established corresponding TM scores. Additionally, the expression level and biological function of tubulin beta 6 class V (TUBB6) were validated in GC tissues and cells. TMC1 was correlated with EMT and TGF-beta pathway and predicted low tumor mutation burden (TMB) as well as bad prognostic outcomes. TMC3 was associated with cell cycle and DNA repair. In terms of TMB and overall survival, TMC3 exhibited opposite results against TMC1. Significant heterogeneity was observed between TMCs. TUBB6 was upregulated and could promote GC proliferation, migration, and invasion. Altogether, combining bioinformatics and functional experiments, we identified three molecular subtypes based on telomere maintenance-associated genes in GC, which could bring new ideas and novel biomarkers to the clinic.

摘要

端粒维持参与胃癌（GC）发病机制的调控，对患者的临床特征至关重要。尽管此前已有关于单个端粒维持相关基因与GC之间相关性的报道，但全面探索和系统分析仍有待研究。我们的研究旨在确定端粒维持相关的分子亚型，并研究它们在GC中的作用。通过分析转录组数据，我们鉴定出三个端粒维持相关簇（TMC），它们在临床特征和肿瘤微环境（TME）方面存在异质性。然后，我们筛选出五个与预后相关的端粒维持相关基因，并建立了相应的TM评分。此外，在GC组织和细胞中验证了微管蛋白β6类V（TUBB6）的表达水平和生物学功能。TMC1与上皮-间质转化（EMT）和转化生长因子-β（TGF-β）途径相关，预测肿瘤突变负荷（TMB）较低以及预后不良。TMC3与细胞周期和DNA修复相关。在TMB和总生存期方面，TMC3与TMC1呈现相反的结果。TMC之间观察到显著的异质性。TUBB6上调并可促进GC的增殖、迁移和侵袭。总之，结合生物信息学和功能实验，我们在GC中基于端粒维持相关基因鉴定出三种分子亚型，这可为临床带来新的思路和新型生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e99/11064253/c3cd42fcdd68/jcav15p3227g009.jpg
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本文引用的文献

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2
Single Cell Analysis of Gastric Cancer Reveals Non-Defined Telomere Maintenance Mechanism.单细胞分析胃癌揭示非定义端粒维持机制。
Cells. 2022 Oct 23;11(21):3342. doi: 10.3390/cells11213342.
3
Tumor microenvironment-mediated immune tolerance in development and treatment of gastric cancer.肿瘤微环境介导的胃癌发生发展及治疗中的免疫耐受。
Front Immunol. 2022 Oct 20;13:1016817. doi: 10.3389/fimmu.2022.1016817. eCollection 2022.
4
Telomeres, Telomerase and Cancer.端粒、端粒酶与癌症
Arch Med Res. 2022 Dec;53(8):741-746. doi: 10.1016/j.arcmed.2022.10.004. Epub 2022 Nov 3.
5
TGF-β controls stromal telomere length through epigenetic modifications.转化生长因子-β通过表观遗传修饰控制基质端粒长度。
3 Biotech. 2022 Nov;12(11):290. doi: 10.1007/s13205-022-03346-5. Epub 2022 Sep 24.
6
Quantitative proteomics identifies TUBB6 as a biomarker of muscle-invasion and poor prognosis in bladder cancer.定量蛋白质组学鉴定 TUBB6 为膀胱癌肌肉浸润和预后不良的标志物。
Int J Cancer. 2023 Jan 15;152(2):320-330. doi: 10.1002/ijc.34265. Epub 2022 Sep 10.
7
Telomere Maintenance and the cGAS-STING Pathway in Cancer.端粒维持与癌症中的 cGAS-STING 通路。
Cells. 2022 Jun 17;11(12):1958. doi: 10.3390/cells11121958.
8
A Novel Pyroptosis-Related Prognostic Signature for Risk Stratification and Clinical Prognosis in Clear Cell Renal Cell Carcinoma.一种新型与细胞焦亡相关的预后标志物用于透明细胞肾细胞癌的风险分层和临床预后评估。
Dis Markers. 2022 Mar 9;2022:8093837. doi: 10.1155/2022/8093837. eCollection 2022.
9
Systematic analysis of migration factors by MigExpress identifies essential cell migration control genes in non-small cell lung cancer.通过 MigExpress 对迁移因子进行系统分析，确定了非小细胞肺癌中细胞迁移控制的关键基因。
Mol Oncol. 2021 Jul;15(7):1797-1817. doi: 10.1002/1878-0261.12973. Epub 2021 May 14.
10
Molecular mechanisms of telomere biology disorders.端粒生物学紊乱的分子机制。
J Biol Chem. 2021 Jan-Jun;296:100064. doi: 10.1074/jbc.REV120.014017. Epub 2020 Nov 22.