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全前臂屈肌复合肌肉动作电位：包涵体肌炎的一种临床生物标志物。

Compound muscle action potential of whole-forearm flexors: A clinical biomarker for inclusion body myositis.

作者信息

Mano Tomoo, Iguchi Naohiko, Iwasa Naoki, Yamada Nanami, Sugie Kazuma

机构信息

Department of Neurology, Nara Medical University, Kashihara, Japan.

Department of Rehabilitation Medicine, Nara Prefecture General Medical Center, Nara, Japan.

出版信息

Clin Neurophysiol Pract. 2024 Apr 12;9:162-167. doi: 10.1016/j.cnp.2024.03.003. eCollection 2024.

DOI:10.1016/j.cnp.2024.03.003
PMID:38707484
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11066998/
Abstract

OBJECTIVE

This study aimed to investigate the potential of whole-forearm flexor muscle (WFFM) compound muscle action potential (CMAP) as a quantitative biomarker for inclusion body myositis (IBM) pathology.

METHODS

We prospectively enrolled 14 consecutive patients (10 men and 4 women) diagnosed with IBM based on muscle biopsies. We evaluated the baseline-to-peak amplitude of the WFFM CMAP and other quantitative parameters, including grip and pinch strength, Inclusion Body Myositis Functional Rating Scale (IBMFRS) score, and other routine muscle CMAP amplitudes.

RESULTS

The WFFM CMAP was strongly correlated with disease duration and the IBMFRS score. The WFFM CMAP on the more affected side was lower than that on the less affected side. Furthermore, grip power was strongly correlated with the WFFM CMAP, whereas lateral pinch strength was strongly correlated with the WFFM and first dorsal interosseous CMAPs. The 3-point pinch strength was also correlated with the WFFM CMAP.

CONCLUSIONS

This study demonstrates that the WFFM CMAP may serve as a biomarker of severity in IBM.

SIGNIFICANCE

Identification of this biomarker can support drug development, diagnosis, prognosis, and treatment options for patients with IBM.

摘要

目的

本研究旨在探讨全前臂屈肌（WFFM）复合肌肉动作电位（CMAP）作为包涵体肌炎（IBM）病理定量生物标志物的潜力。

方法

我们前瞻性地纳入了14例经肌肉活检确诊为IBM的连续患者（10例男性和4例女性）。我们评估了WFFM CMAP的基线至峰值幅度以及其他定量参数，包括握力和捏力、包涵体肌炎功能评定量表（IBMFRS）评分以及其他常规肌肉CMAP幅度。

结果

WFFM CMAP与疾病持续时间和IBMFRS评分密切相关。受影响较重一侧的WFFM CMAP低于受影响较轻一侧。此外，握力与WFFM CMAP密切相关，而侧捏力与WFFM和第一背侧骨间肌CMAP密切相关。三点捏力也与WFFM CMAP相关。

结论

本研究表明，WFFM CMAP可能作为IBM严重程度的生物标志物。

意义

识别这种生物标志物可为IBM患者的药物开发、诊断、预后和治疗选择提供支持。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ad0/11066998/e4983128fc30/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ad0/11066998/bca55272f71d/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ad0/11066998/4692d655fda7/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ad0/11066998/e4983128fc30/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ad0/11066998/bca55272f71d/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ad0/11066998/4692d655fda7/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ad0/11066998/e4983128fc30/gr3.jpg

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Electromyography varies by stage in inclusion body myositis.肌电图在包涵体肌炎的不同阶段有所不同。
Front Neurol. 2024 Jan 5;14:1295396. doi: 10.3389/fneur.2023.1295396. eCollection 2023.
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Clin Neurophysiol Pract. 2023 Jun 29;8:132-136. doi: 10.1016/j.cnp.2023.05.004. eCollection 2023.
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Correlations of disease severity outcome measures in inclusion body myositis.
包涵体肌炎疾病严重程度结局测量指标的相关性。
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Quantitative MRI Biomarkers as Potential Inclusion Body Myositis Clinical Trial Endpoints.
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