• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

应对复杂性：噬血细胞性淋巴组织细胞增生症诊断与管理挑战的案例研究

Navigating Complexity: A Case Study on Hemophagocytic Lymphohistiocytosis Diagnosis and Management Challenges.

作者信息

Nguyen Julie, Tun Nattapron, Burley Nick, Bolos David

机构信息

Internal Medicine, St. Joseph's Medical Center, Stockton, USA.

Hematology and Oncology, Olive View-University of California Los Angeles Medical Center, Los Angeles, USA.

出版信息

Cureus. 2024 May 4;16(5):e59628. doi: 10.7759/cureus.59628. eCollection 2024 May.

DOI:10.7759/cureus.59628
PMID:38707754
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11070218/
Abstract

Hemophagocytic lymphohistiocytosis (HLH) is a severe inflammatory disorder that affects multiple organ systems and carries a high risk of mortality if untreated. Treatment typically involves immune suppression with steroids and cytotoxic drugs. This case report details the evaluation and management of an adult female presenting with atypical symptoms, aims to improve awareness and understanding of HLH in adults, and emphasizes the urgency of timely diagnosis and intervention.

摘要

噬血细胞性淋巴组织细胞增生症（HLH）是一种严重的炎症性疾病，可影响多个器官系统，若不治疗，死亡率很高。治疗通常包括使用类固醇和细胞毒性药物进行免疫抑制。本病例报告详细介绍了一名出现非典型症状的成年女性的评估和管理情况，旨在提高对成人HLH的认识和理解，并强调及时诊断和干预的紧迫性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1d5/11070218/25fd36cc2c84/cureus-0016-00000059628-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1d5/11070218/f9d12caeb8c1/cureus-0016-00000059628-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1d5/11070218/85002552901e/cureus-0016-00000059628-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1d5/11070218/25fd36cc2c84/cureus-0016-00000059628-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1d5/11070218/f9d12caeb8c1/cureus-0016-00000059628-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1d5/11070218/85002552901e/cureus-0016-00000059628-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1d5/11070218/25fd36cc2c84/cureus-0016-00000059628-i03.jpg

相似文献

1
Navigating Complexity: A Case Study on Hemophagocytic Lymphohistiocytosis Diagnosis and Management Challenges.应对复杂性：噬血细胞性淋巴组织细胞增生症诊断与管理挑战的案例研究
Cureus. 2024 May 4;16(5):e59628. doi: 10.7759/cureus.59628. eCollection 2024 May.
2
A Case of Severe Epstein-Barr Virus-Associated Hemophagocytic Lymphohistiocytosis Successfully Treated With High Dose Steroids and Ganciclovir.一例严重的爱泼斯坦-巴尔病毒相关噬血细胞性淋巴组织细胞增生症经大剂量类固醇和更昔洛韦成功治疗的病例
Cureus. 2022 Jun 15;14(6):e25952. doi: 10.7759/cureus.25952. eCollection 2022 Jun.
3
Epstein-Barr Virus-Related Hemophagocytic Lymphohistiocytosis with Central Nervous System Symptoms.伴有中枢神经系统症状的爱泼斯坦-巴尔病毒相关噬血细胞性淋巴组织细胞增生症
J Nippon Med Sch. 2023 Mar 11;90(1):126-135. doi: 10.1272/jnms.JNMS.2023_90-105. Epub 2022 Nov 25.
4
Not another case of mono: Epstein-Barr virus (EBV) associate hemophagocytic lymphohistiocytosis (HLH).不是又一例传染性单核细胞增多症：爱泼斯坦-巴尔病毒（EBV）相关噬血细胞性淋巴组织细胞增生症（HLH）。
Am J Case Rep. 2013 Dec 6;14:529-31. doi: 10.12659/AJCR.889322. eCollection 2013.
5
Hemophagocytic lymphohistiocytosis associated with Epstein-Barr virus-positive diffuse large B-cell lymphoma, NOS of bone marrow-liver-spleen type: an autopsy case report.噬血细胞性淋巴组织细胞增生症合并 EBV 阳性弥漫性大 B 细胞淋巴瘤，NOS，骨髓-肝-脾型：一例尸检病例报告。
J Clin Exp Hematop. 2021 Jun 5;61(2):102-108. doi: 10.3960/jslrt.20053. Epub 2021 May 14.
6
Hemophagocytic Lymphohistiocytosis as the Presenting Manifestation of Relapsed Classic Hodgkin's Lymphoma in the Presence of Concurrent Human Immunodeficiency Virus, Genital Herpes, Epstein-Barr Virus and Mycobacterium Avium Complex Infection.噬血细胞性淋巴组织细胞增生症作为复发性经典型霍奇金淋巴瘤在合并人类免疫缺陷病毒、生殖器疱疹、爱泼斯坦-巴尔病毒及鸟分枝杆菌复合群感染时的首发表现
Cureus. 2020 Nov 19;12(11):e11563. doi: 10.7759/cureus.11563.
7
Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis in a small child: A case report.一名幼儿的爱泼斯坦-巴尔病毒相关噬血细胞性淋巴组织细胞增生症：病例报告
Medicine (Baltimore). 2020 Jan;99(3):e18759. doi: 10.1097/MD.0000000000018759.
8
Ruxolitinib is an alternative to etoposide for patient with hemophagocytic lymphohistiocytosis complicated by acute renal injury: A case report.芦可替尼可作为急性肾损伤合并噬血细胞性淋巴组织细胞增生症患者的依托泊苷替代药物：病例报告。
J Oncol Pharm Pract. 2022 Jan;28(1):222-227. doi: 10.1177/10781552211020821. Epub 2021 Jun 1.
9
Rituximab, etoposide, methylprednisolone, high-dose cytarabine, and cisplatin in the treatment of secondary hemophagocytic lymphohistiocytosis with classical Hodgkin lymphoma: a case report and review of the literature.利妥昔单抗、依托泊苷、甲泼尼龙、大剂量阿糖胞苷和顺铂治疗伴经典型霍奇金淋巴瘤的继发性噬血细胞性淋巴组织细胞增生症：1例报告并文献复习
J Med Case Rep. 2016 Dec 20;10(1):365. doi: 10.1186/s13256-016-1143-9.
10
Hemophagocytic Lymphohistiocytosis in Renal Transplant Recipients: A 2-Case Report.肾移植受者中的噬血细胞性淋巴组织细胞增生症：2例报告
Transplant Proc. 2020 Jun;52(5):1566-1569. doi: 10.1016/j.transproceed.2020.02.047. Epub 2020 May 8.

本文引用的文献

1
Q fever as a rare cause of hemophagocytic lymphohistiocytosis: Case report.Q 热作为噬血细胞性淋巴组织细胞增生症的罕见病因：病例报告。
Transfus Apher Sci. 2020 Aug;59(4):102747. doi: 10.1016/j.transci.2020.102747. Epub 2020 Feb 28.
2
Hemophagocytic Syndrome-An Approach to the Management.噬血细胞综合征——管理方法
Indian J Crit Care Med. 2019 Sep;23(Suppl 3):S191-S196. doi: 10.5005/jp-journals-10071-23251.
3
Challenges in the diagnosis of hemophagocytic lymphohistiocytosis: Recommendations from the North American Consortium for Histiocytosis (NACHO).
噬血细胞性淋巴组织细胞增生症诊断中的挑战：北美组织细胞增生症联盟（NACHO）的建议。
Pediatr Blood Cancer. 2019 Nov;66(11):e27929. doi: 10.1002/pbc.27929. Epub 2019 Jul 24.
4
Recommendations for the management of hemophagocytic lymphohistiocytosis in adults.成人噬血细胞性淋巴组织细胞增生症的治疗建议。
Blood. 2019 Jun 6;133(23):2465-2477. doi: 10.1182/blood.2018894618. Epub 2019 Apr 16.
5
and Haemophagocytic Syndrome.以及噬血细胞综合征。
Am J Trop Med Hyg. 2017 Nov;97(5):1632. doi: 10.4269/ajtmh.17-0606.
6
How to Treat Involvement of the Central Nervous System in Hemophagocytic Lymphohistiocytosis?如何治疗噬血细胞性淋巴组织细胞增生症的中枢神经系统受累？
Curr Treat Options Neurol. 2017 Jan;19(1):3. doi: 10.1007/s11940-017-0439-4.
7
Development and validation of the HScore, a score for the diagnosis of reactive hemophagocytic syndrome.HScore 的制定与验证：一种用于诊断反应性噬血细胞综合征的评分系统。
Arthritis Rheumatol. 2014 Sep;66(9):2613-20. doi: 10.1002/art.38690.
8
Prognostic factors and outcomes of adults with hemophagocytic lymphohistiocytosis.噬血细胞性淋巴组织细胞增生症成人的预后因素和转归。
Mayo Clin Proc. 2014 Apr;89(4):484-92. doi: 10.1016/j.mayocp.2013.12.012. Epub 2014 Feb 26.
9
Epstein-barr virus-induced hemophagocytic lymphohistiocytosis.爱泼斯坦-巴尔病毒诱导的噬血细胞性淋巴组织细胞增生症
Int J Hematol Oncol Stem Cell Res. 2013;7(1):42-5.
10
Etoposide selectively ablates activated T cells to control the immunoregulatory disorder hemophagocytic lymphohistiocytosis.依托泊苷选择性清除活化的 T 细胞以控制免疫调节紊乱噬血细胞性淋巴组织细胞增生症。
J Immunol. 2014 Jan 1;192(1):84-91. doi: 10.4049/jimmunol.1302282. Epub 2013 Nov 20.