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骨关节炎中线粒体相关内质网膜相关基因与细胞衰老相关基因的相关性

Correlation between Mitochondria-Associated Endoplasmic Reticulum Membrane-Related Genes and Cellular Senescence-Related Genes in Osteoarthritis.

作者信息

Li Hui-Min, Wang Chenhuan, Liu Qixue, Tong Zhicheng, Song Binghua, Wei Wei, Teng Chong

机构信息

Department of Orthopedics, The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, Zhejiang 322000, PR China.

出版信息

ACS Omega. 2024 Apr 15;9(17):19169-19181. doi: 10.1021/acsomega.3c10316. eCollection 2024 Apr 30.

DOI:10.1021/acsomega.3c10316
PMID:38708239
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11064197/
Abstract

BACKGROUND

The role of mitochondria-associated endoplasmic reticulum membrane (MAM) formation in the development of osteoarthritis (OA) is yet unclear.

METHODS

A mix of bioinformatics methods and experimental methodologies was used to study and corroborate the role of MAM-related genes and cellular senescence-related genes in the development of OA. The Gene Expression Omnibus database was used to obtain the microarray information that is relevant to the OA. Several bioinformatic methods were employed to carry out function enrichment analysis and protein-protein correlation analysis, build the correlation regulatory network, and investigate potential relationships between MAM-related genes and cellular senescence-related genes in OA. These methods also served to identify the MAM-related and OA-related genes (MAM-OARGs).

RESULTS

For the additional functional enrichment analysis, a total of 13 MAM-OARGs were detected. The correlation regulatory network was also created. Hub MAM-OARGs were shown to have a strong correlation with genes relevant to cellular senescence in OA. Results of experiments further demonstrated a positive correlation between MAM-OARGs (PTPN1 and ITPR1) and cellular senescence-related and OA-related genes.

CONCLUSIONS

As a result, our findings can offer new insights into the investigations of MAM-related genes and cellular senescence-related genes, which could be linked to the OA as well as brand-new potential treatment targets.

摘要

背景

线粒体相关内质网膜（MAM）形成在骨关节炎（OA）发展中的作用尚不清楚。

方法

采用生物信息学方法和实验方法相结合的方式，研究并证实MAM相关基因和细胞衰老相关基因在OA发展中的作用。利用基因表达综合数据库获取与OA相关的微阵列信息。采用多种生物信息学方法进行功能富集分析和蛋白质-蛋白质相关性分析，构建相关调控网络，研究OA中MAM相关基因与细胞衰老相关基因之间的潜在关系。这些方法还用于鉴定MAM相关和OA相关基因（MAM-OARGs）。

结果

在额外的功能富集分析中，共检测到13个MAM-OARGs。还创建了相关调控网络。枢纽MAM-OARGs显示出与OA中细胞衰老相关基因有很强的相关性。实验结果进一步证明了MAM-OARGs（PTPN1和ITPR1）与细胞衰老相关和OA相关基因之间存在正相关。

结论

因此，我们的研究结果可为MAM相关基因和细胞衰老相关基因的研究提供新的见解，这些基因可能与OA有关，也是全新的潜在治疗靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c356/11064197/c9859db21978/ao3c10316_0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c356/11064197/493502b24de1/ao3c10316_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c356/11064197/5d7bd3293e24/ao3c10316_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c356/11064197/4776f5b7d7e7/ao3c10316_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c356/11064197/233038731333/ao3c10316_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c356/11064197/478f24b47bbd/ao3c10316_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c356/11064197/4fb42f379083/ao3c10316_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c356/11064197/bfce8c209d60/ao3c10316_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c356/11064197/ffbbaa8dffa2/ao3c10316_0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c356/11064197/c9859db21978/ao3c10316_0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c356/11064197/493502b24de1/ao3c10316_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c356/11064197/5d7bd3293e24/ao3c10316_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c356/11064197/4776f5b7d7e7/ao3c10316_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c356/11064197/233038731333/ao3c10316_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c356/11064197/478f24b47bbd/ao3c10316_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c356/11064197/4fb42f379083/ao3c10316_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c356/11064197/bfce8c209d60/ao3c10316_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c356/11064197/ffbbaa8dffa2/ao3c10316_0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c356/11064197/c9859db21978/ao3c10316_0009.jpg

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