Eurolens Research, Division of Pharmacy and Optometry, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.
Johnson & Johnson Vision, Inc, Jacksonville, Florida, USA.
Ophthalmic Physiol Opt. 2024 Jul;44(5):894-909. doi: 10.1111/opo.13321. Epub 2024 May 6.
To investigate whether there is a measurable change in meibomian gland morphological characteristics over the course of a day (12 h) and over a month.
The study enrolled 15 participants who attended a total of 11 study visits spanning a 5-week period. To assess diurnal changes in meibomian glands, seven visits were conducted on a single day, each 2 h apart. For monthly assessment, participants attended an additional visit at the same time of the day every week for three consecutive weeks. Meibography using the LipiView® II system was performed at each visit, and meibomian gland morphological parameters were calculated using custom semi-automated software. Specifically, six central glands were analysed for gland length ratio, gland width, gland area, gland intensity and gland tortuosity.
The average meibomian gland morphological metrics did not exhibit significant changes during the course of a day or over a month. Nonetheless, certain individual gland metrics demonstrated notable variation over time, both diurnally and monthly. Specifically, meibomian gland length ratio, area, width and tortuosity exhibited significant changes both diurnally and monthly when assessed on a gland-by-gland basis.
Meibomian glands demonstrated measurable structural change over short periods of time (hours and days). These results have implications for innovation in gland imaging and for developing precision monitoring of gland structure to assess meibomian gland health more accurately.
研究在一天（12 小时）和一个月的时间内，睑板腺形态特征是否会发生可测量的变化。
该研究纳入了 15 名参与者，他们共参加了 11 次研究访问，历时 5 周。为了评估睑板腺的昼夜变化，在一天内进行了 7 次 2 小时间隔的访问。为了进行每月评估，参与者每周在同一时间参加另外一次访问，连续进行 3 周。在每次访问时使用 LipiView® II 系统进行睑板腺照相，并使用定制的半自动软件计算睑板腺形态参数。具体来说，对 6 个中央腺体进行分析，以测量腺体长度比、腺体宽度、腺体面积、腺体强度和腺体扭曲度。
在一天或一个月的时间内，平均睑板腺形态学指标没有明显变化。然而，某些个体腺体指标在时间上存在显著的变化，无论是昼夜变化还是每月变化。具体来说，当逐腺评估时，睑板腺长度比、面积、宽度和扭曲度在昼夜和每月都有显著变化。
睑板腺在短时间内（小时和天）表现出可测量的结构变化。这些结果对腺体成像的创新以及开发精确监测腺体结构以更准确地评估睑板腺健康具有重要意义。
