Department of Ophthalmology, Erciyes University School of Medicine, Kayseri, Turkey.
Eye Contact Lens. 2020 Mar;46 Suppl 2:S135-S140. doi: 10.1097/ICL.0000000000000651.
To investigate the correlation between the clinical grading of the severity of meibomian gland dysfunction (MGD) and meibomian gland area (MGA) loss detected using Sirius meibography in the upper and lower eyelids and to correlate these parameters with dry eye signs and symptoms.
One hundred thirty eyes of 130 volunteer patients were enrolled. Meibomian gland dysfunction was defined as the presence of signs consistent with meibomian gland terminal duct obstruction and categorized between grades 1 and 4. Upper and lower MGA loss percentages were evaluated using Sirius meibography by two blinded examiners. Patients were categorized into two groups (positive and negative for MGD) based on their Ocular Surface Disease Index (OSDI) scores (≥15 and <14, respectively) and MGD grades (≥1 and 0, respectively).
The MGA loss percentage and ocular surface test results of the MGD group were greater than in the non-MGD group in both eyelids (P=0.001). Meibomian gland dysfunction grade and MGA loss for the lower eyelid was greater than that of the upper eyelids (P=0.002 and P<0.001, respectively). The OSDI score, tear film break-up time, and lissamine green staining were all significantly correlated with MGD grade and MGA loss in both eyelids (P<0.001). For the average measures of the MGA loss percentage in each scan, the intraclass correlation value was found as 0.994 (95% confidence interval [CI]: 0.992-0.995) for reader 1 and 0.988 (95% CI: 0.982-0.992) for reader 2.
Our findings suggest that Sirius meibography, a noncontact imaging device, is a reliable tool for evaluating meibomian gland structure in patients with MGD and non-MGD of various ages and regardless of sex.
研究 Sirius 睑板腺照相在上、下眼睑检测到的睑板腺功能障碍（MGD）严重程度的临床分级与睑板腺面积（MGA）丧失之间的相关性，并将这些参数与干眼体征和症状相关联。
纳入 130 名志愿者患者的 130 只眼。MGD 定义为存在符合睑板腺终末导管阻塞的体征，并分为 1 至 4 级。使用 Sirius 睑板腺照相仪由两名盲法检查者评估上、下睑 MGA 丧失的百分比。根据眼表疾病指数（OSDI）评分（分别为≥15 和<14）和 MGD 分级（分别为≥1 和 0）将患者分为 MGD 阳性和阴性两组。
上、下眼睑 MGD 组的 MGA 丧失百分比和眼部测试结果均大于非 MGD 组（P=0.001）。下眼睑的 MGD 分级和 MGA 丧失大于上眼睑（P=0.002 和 P<0.001）。OSDI 评分、泪膜破裂时间和丽丝胺绿染色均与上下眼睑的 MGD 分级和 MGA 丧失显著相关（P<0.001）。对于每个扫描的 MGA 丧失百分比的平均测量值，读者 1 的组内相关值为 0.994（95%置信区间[CI]：0.992-0.995），读者 2 的为 0.988（95% CI：0.982-0.992）。
我们的研究结果表明，非接触成像设备 Sirius 睑板腺照相术是一种可靠的工具，可用于评估各种年龄和性别 MGD 与非 MGD 患者的睑板腺结构。
